Results 81 to 90 of about 22,572 (280)
, 2021 Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have
Jasmine Rowell (7004801) +6 more
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Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling
FEBS Open Bio, EarlyView.Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt +2 more
wiley +1 more source
Patched1 and Patched2 inhibit Smoothened non-cell autonomously
eLife, 2016 Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates
Brock Roberts +4 more
doaj +1 more source
, 1977 smoothenedWe would launch our dory sometimes when rough seas rolled in the cove. We would have to wait considerable time before the sea smoothened to launch. We would row to our seven herring nets, haul them and pick out the herring.PRINTED ITEM
core
Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani +10 more
wiley +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced ScienceSensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies.
Huanyu Mao +9 more
doaj +1 more source
Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells
Tumor Biology, 2017 Previous studies report aberrant activation of the hedgehog signaling pathway in the progression of various cancers. This study aimed to investigate the expressions of smoothened and downstream glioma-associated oncogene homology-1 in gastric cancer and ...
Zixin Yang +6 more
doaj +1 more source
A frequent activated smoothened mutation in sporadic basal cell carcinomas
, 1999 Basal-cell carcinomas (BCCs) are the most common cancer in Caucasians. It has been reported that the patched gene is inactivated in 30-40% sporadic BCCs and 20% sporadic medulloblastomas via loss of heterozygosity and nonsense mutations.
Chan, LYS +9 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou +16 more
wiley +1 more source
Glucocorticoids get Smoothened [PDF]
Science-Business eXchange, 2010 Duke researchers have identified multiple FDA-approved glucocorticoids that exhibit Smoothened agonist activity and can stimulate the proliferation of primary neuronal precursor cells. The proven safety records for these glucocorticoids could mean accelerated repurposing in various tissue repair and regenerative medicine applications.
openaire +1 more source