Results 81 to 90 of about 29,268 (294)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Automatic segmentation of Phonocardiogram using the occurrence of the cardiac events
Informatics in Medicine Unlocked, 2017 Objective: This paper presents automatic method of segmentation of heart sound using the occurrence of the cardiac rhythmic events. Methods: Noisy heart sound is filtered using the 6th order Chebyshev type I low pass filter to remove the redundant noise.
M. Vishwanath Shervegar, Ganesh V. Bhat
doaj +1 more source
Integration of SHH and WNT pathways controls morphogenesis of the CNS. [PDF]
, 2008 [eng] Dorsoventral patterning of the vertebrate nervous system is achieved by the combined activity of morphogenetic signals secreted from dorsal and ventral signalling centres. The Shh/Gli pathway plays a major role in patterning the ventral neural tube;
Álvarez Medina, José Roberto
core
Hedgehog Signalling: Pulling Apart Patched and Smoothened
, 2002 Two integral membrane proteins, Patched and Smoothened, were for a long time thought to comprise a preformed receptor complex for secreted Hedgehog signalling proteins.
Stark, David R
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Current Opinion in Structural Biology, 2019 The Hedgehog (HH) signalling pathway is a cell-cell communication system that controls the patterning of multiple tissues during embryogenesis in metazoans. In adults, HH signals regulate tissue stem cells and regenerative responses.
C. Kowatsch +4 more
semanticscholar +1 more source
Journal of Cell Science, 2020 Sonic hedgehog (Shh) and its patched–smoothened receptor complex control a variety of functions in the developing central nervous system, such as neural cell proliferation and differentiation.
Quentin Delmotte +6 more
semanticscholar +1 more source
Conservation and divergence of the "Nematostella vectensis" Smoothened Homolog
, 2022 Der Hedgehog-Signalweg ist einer der wichtigsten Signalwege in der tierischen Embryonalentwicklung und Zellhomöostase. Die Hauptkomponenten dieses Signalwegs wurden in verschiedensten Spezies gefunden und die Mechanismen, die diesen Signalweg regulieren ...
Regele, Dominik
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Ashworth, R +7 more
core +1 more source