Results 101 to 110 of about 29,268 (294)
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
PLoS ONE, 2013 The importance of microRNAs in development is now widely accepted. However, identifying the specific targets of individual microRNAs and understanding their biological significance remains a major challenge.
Ami Ketley +5 more
doaj +1 more source
ZNF423 knockdown quantitatively alters Smoothened translocation.
, 2016 (A) RT-PCR shows Zfp423 expression in mouse P19 cells [32] and ZNF423 RNA expression in DAOY medulloblastoma cells. GAPDH was used as a positive control. M, size marker.
Chen-Jei Hong (418943) +1 more
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Cilia-Mediated Hedgehog Signaling in Drosophila
Cell Reports, 2014 Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers.
Anujaianthi Kuzhandaivel +3 more
doaj +1 more source
E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation
Journal of Molecular Cell Biology, 2019 Hedgehog (Hh) signalling plays conserved roles in controlling embryonic development; its dysregulation causes many diseases including cancers. The G protein-coupled receptor Smoothened (Smo) is the key signal transducer of the Hh pathway, whose ...
Weirong Jiang +5 more
semanticscholar +1 more source
, 1977 smoothenedWe would launch our dory sometimes when rough seas rolled in the cove. We would have to wait considerable time before the sea smoothened to launch. We would row to our seven herring nets, haul them and pick out the herring.PRINTED ITEM
core
Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
, 2016 The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was performed, and the lead structure (1) was identified as an inhibitor of the Hh pathway via ...
Yun Jiang (534502) +27 more
core +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
, 2016 Smoothened is a critical component of the Hedgehog pathway that is essential for stem cell renewal and is dysregulated in many cancer types. We have found synthetic analogues of the second and third intracellular loops of smoothened to be potent ...
Hong Lou (2477365) +4 more
core +2 more sources