Results 111 to 120 of about 29,268 (294)

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Cancer Cell, 2014
Summary Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable.
M. Kool, David T. W. Jones, N. Jäger, P. Northcott, Trevor J Pugh, V. Hovestadt, R. Piro, L. Esparza, S. Markant, M. Remke, T. Milde, F. Bourdeaut, M. Ryzhova, D. Sturm, E. Pfaff, S. Stark, S. Hutter, H. Şeker-Cin, P. Johann, S. Bender, Christin Schmidt, T. Rausch, D. Shih, J. Reimand, Laura Sieber, A. Wittmann, Linda Linke, H. Witt, Ursula D. Weber, M. Zapatka, R. König, R. Beroukhim, G. Bergthold, P. V. van Sluis, R. Volckmann, J. Koster, R. Versteeg, Sabine Schmidt, S. Wolf, C. Lawerenz, C. Bartholomae, C. von Kalle, A. Unterberg, C. Herold‐Mende, S. Hofer, A. Kulozik, A. von Deimling, W. Scheurlen, J. Felsberg, G. Reifenberger, M. Hasselblatt, J. Crawford, G. Grant, N. Jabado, A. Perry, Cynthia Cowdrey, S. Croul, G. Zadeh, J. Korbel, F. Doz, O. Delattre, Gary D Bader, M. McCabe, V. Collins, M. Kieran, Yoon-Jae Cho, S. Pomeroy, O. Witt, B. Brors, Michael D. Taylor, U. Schüller, A. Korshunov, R. Eils, R. Wechsler-Reya, P. Lichter, S. Pfister   +75 more
semanticscholar   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

Cell Research, 2022
Ao Hu, Jing-Zan Zhang, Jie Wang, Chen-Chen Li, Meng Yuan, Gang Deng, Zifan Lin, Zhi-Ping Qiu, H. Liu, Xianwei Wang, Pengcheng Wei, Xiao He, Xiaolu Zhao, Wen-Wei Qiu, B. Song   +14 more
semanticscholar   +1 more source

CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance There have been FDA-approved anti-hedgehog drugs for treating hedgehog-driven cancers, which act by antagonizing the upstream component smoothened; however, resistance to smoothened inhibitor (SMOi) drugs have been described.
Fang Liu, Wenyan Jiang, Yi Sui, Wei Meng, Linjun Hou, Tiantian Li, Meng Li, Lei Zhang, Jialin Mo, Jiajia Wang, Yang Zhao, Liye Zhang, Jie Ma, Yujie Tang   +13 more
semanticscholar   +1 more source

Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design

, 2014
Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation or inhibition is considered a potential powerful tool in regenerative medicine and for the treatment of cancer.
Maurizio Taddei, Petricci, Elena, Fabrizio Manetti, Taddei, Maurizio, Elena Petricci, Manetti, Fabrizio   +5 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells

Tumor Biology, 2017
Previous studies report aberrant activation of the hedgehog signaling pathway in the progression of various cancers. This study aimed to investigate the expressions of smoothened and downstream glioma-associated oncogene homology-1 in gastric cancer and ...
Zixin Yang, Yingqian Lv, Long Wang, Yong Chen, Jinzhu Han, Shan Zhao, Wei Liu   +6 more
doaj   +1 more source

Patched1 and Patched2 inhibit Smoothened non-cell autonomously

eLife, 2016
Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates
Brock Roberts, Catalina Casillas, Astrid C Alfaro, Carina Jägers, Henk Roelink   +4 more
doaj   +1 more source

Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling

, 2011
It takes two kinases and two phosphatases acting on a single membrane protein Smoothened to interpret the Hedgehog morphogen gradient.
Junzheng Zhang, Andrew P. Michelson, Jason K. Ospina, Alan Jian Zhu, Adam M. Schoen, Ying Su   +5 more
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source