Results 121 to 130 of about 29,268 (294)

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

Journal of Cell Biology, 2016
Pal et al. describe a two-step process determining removal of the cilia-localized GPCR, Gpr161, upon sonic hedgehog signaling. First, β-arrestins are recruited by the signaling-competent receptor in a smoothened-dependent manner.
Kasturi Pal, Sun-Hee Hwang, B. Somatilaka, H. Badgandi, P. Jackson, K. DeFea, Saikat Mukhopadhyay   +6 more
semanticscholar   +1 more source

Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

, 2017
Malignant gliomas are associated with a high mortality rate. Thus, there is an urgent need for the development of novel targeted therapeutics. Aberrant Hedgehog signaling has been directly linked to glioma. GDC-0449 is a novel small molecule inhibitor of
Shangfeng Gao, Peng Xie, Zhenglei Qi, Qiong Shi, Chenglong Yue, Ning Liu, Mingshan Niu, Xuejiao Liu, Hongmei Liu, Rutong Yu, Yiming Tu   +10 more
core   +1 more source

Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened

, 2020
Vlk is a secreted tyrosine kinase that plays crucial roles during vertebrate embryonic development including skeletal formation. Genetic studies suggest that Vlk can modulate the Hedgehog signaling pathway during skeletal development.
여창열
core   +1 more source

Temporal and spatial requirements of Smoothened in ventral midbrain neuronal development [PDF]

, 2013
Background Several studies have indicated that Sonic hedgehog (Shh) regulates the expansion of dopaminergic (DA) progenitors and the subsequent generation of mature DA neurons.
Luo, Sarah, Tang, V, Huang, Eric, Tang, Mianzhi, Huang, Eric J, Tang, Vivian, Luo, Sarah X, Tang, M, Huang, EJ, Luo, SX   +9 more
core   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Mise en place et rôle de la localisation apico-basale de la GPCR Smoothened dans la voie de signalisation Hedgehog

, 2022
La protéine oncogénique Smoothened de la famille des récepteurs couplés au protéine G (GPCR) est un transducteur clé de la voie de signalisation Hedgehog, qui joue un rôle essentiel dans la mise en place des structures épithéliales. Au cours de ma thèse,
Gonçalves Antunes, Marina
core  

Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon+ α-Cells

Nature Cell Biology, 2018
The mechanisms that restrict regeneration and maintain cell identity following injury are poorly characterized in higher vertebrates. Following β-cell loss, 1–2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice.
V. Cigliola, Luiza M. Ghila, F. Thorel, Léon van Gurp, D. Baronnier, Daniel Oropeza, Simone Gupta, T. Miyatsuka, H. Kaneto, M. Magnuson, Anna B. Osipovich, M. Sander, C. Wright, Melissa K Thomas, Kenichiro Furuyama, S. Chera, P. Herrera   +16 more
semanticscholar   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

mTORC1 hampers Hedgehog signaling in Tsc2 deficient cells

Life Science Alliance
This is the first demonstration that mTORC1 inhibits Hedgehog signaling. mTORC1 prevents cilia accumulation of Smo and activation of GlI2. Also, evidence is provided for a 2-step activation process of GLI2.
Lasse Jonsgaard Larsen, Elsebet Østergaard, Lisbeth Birk Møller   +2 more
doaj   +1 more source