Results 31 to 40 of about 29,268 (294)
Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle
Current Issues in Molecular Biology, 2022 Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the hepatic architecture involve multiple signaling pathways. It has been reported that the Hh signal is
Jiawang Tao +7 more
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An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
EMBO Reports, 2021 HONORS AND AWARDS • Fellowship Award, Damon Runyon Cancer Research Fund (2006) • Howard Temin Pathway to Independance Award (K99/R00), NCI/NIH (2007) • Young Investigator Award, American Society for Clinical Oncology (2007) • Josephine Q.
Zhonghua Zhao +5 more
semanticscholar +1 more source
Activation of the Hedgehog and Wnt/β-Catenin Signaling Pathways in Basal Cell Carcinoma
Case Reports in Dermatology, 2021 In basal cell carcinoma (BCC) tumorigenesis, interaction between Hedgehog (Hh) and Wnt/β-catenin (Wnt) signaling pathways has been investigated, but not completely elucidated.
Tomoaki Takada
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The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
Biomedicines, 2021 The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved among mammals, with crucial roles in regulating embryonic development as well as in cancer initiation and progression.
J. Chai +6 more
semanticscholar +1 more source
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Nature Chemical Biology, 2020 Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine-rich domain (CRD) and to several sites in the seven transmembrane ...
Xiaofeng Qi +4 more
semanticscholar +1 more source
bioRxiv, 2020 The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO ...
Corvin D. Arveseth +16 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 Medulloblastoma is an aggressive pediatric brain tumor that can be driven by misactivation of the Hedgehog (HH) pathway. CDK6 is a critical effector of oncogenic Hedgehog signaling, but attempts to target the Hedgehog pathway in medulloblastoma have been
V. Daggubati +10 more
semanticscholar +1 more source
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
eLife, 2013 The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (
Sigrid Nachtergaele +9 more
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Frontiers in Genetics, 2019 The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical role in controlling cell specification, cell–cell interaction and tissue patterning during embryonic development.
Silvia Pietrobono +2 more
semanticscholar +1 more source
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
Nature, 2019 Hedgehog signalling is fundamental to embryonic development and postnatal tissue regeneration1. Aberrant postnatal Hedgehog signalling leads to several malignancies, including basal cell carcinoma and paediatric medulloblastoma2.
I. Deshpande +11 more
semanticscholar +1 more source