Results 31 to 40 of about 41,949 (243)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Estimation of intrinsic diffusion coefficients in a pseudo-binary diffusion couple
, 2015 Major drawback of studying diffusion in multi-component systems is the lack of suitable techniques to estimate the diffusion parameters. In this study, a generalized treatment to determine the intrinsic diffusion coefficients in multi-component systems ...
Paul, Aloke, Santra, Sangeeta
core +1 more source
Monotonicity preserving approximation of multivariate scattered data [PDF]
, 2005 This paper describes a new method of monotone interpolation and smoothing of multivariate scattered data. It is based on the assumption that the function to be approximated is Lipschitz continuous.
Beliakov, Gleb
core +1 more source
Structure du récepteur Smoothened [PDF]
médecine/sciences, 2013 The Smoothened (Smo) receptor is a major component involved in signal transduction of the Hedgehog (Hh) morphogens both during embryogenesis and in the adult. Smo antagonists represent a promi-sing alternative for the treatment of cancers linked to abnormal Hh signalling.
Martial Ruat +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Small molecule modulation of Smoothened activity [PDF]
Proceedings of the National Academy of Sciences, 2002 Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation in tumorigenesis. Although the cellular mechanisms that regulate Smo function remain unclear, the direct inhibition of Smo by cyclopamine, a plant-derived ...
James K, Chen +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Persistent currents in a Bose-Einstein condensate in the presence of disorder
, 2007 We examine bosonic atoms that are confined in a toroidal, quasi-one-dimensional trap, subjected to a random potential. The resulting inhomogeneous atomic density is smoothened for sufficiently strong, repulsive interatomic interactions.
A.D. Jackson +34 more
core +1 more source
Glucocorticoids get Smoothened [PDF]
Science-Business eXchange, 2010 Duke researchers have identified multiple FDA-approved glucocorticoids that exhibit Smoothened agonist activity and can stimulate the proliferation of primary neuronal precursor cells. The proven safety records for these glucocorticoids could mean accelerated repurposing in various tissue repair and regenerative medicine applications.
openaire +1 more source