Results 11 to 20 of about 29,268 (294)

Identification of Novel Smoothened Ligands Using Structure-Based Docking. [PDF]

PLoS ONE, 2016
The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and ...
Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers   +6 more
doaj   +3 more sources

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The Hedgehog pathway is critical in development and disease, but how cells respond to the secreted Hedgehog signal remains mysterious.
Benjamin R Myers, Lila Neahring, Yunxiao Zhang   +2 more
exaly   +3 more sources

Smoothened-dependent and -independent pathways in mammalian noncanonical Hedgehog signaling

Journal of Biological Chemistry, 2019
Hedgehog proteins are pivotal morphogens acting through a canonical pathway involving first activation of ligand binding to Patched followed by alleviation of Smoothened receptor inhibition, leading to activation of Gli transcription factors ...
Alessandra V. de S. Faria, Alessandra V. de S. Faria, A. Akyala, A. Akyala, K. Parikh, L. W. Brüggemann, C. Spek, W. Cao, M. Bruno, M. Bijlsma, G. Fuhler, M. Peppelenbosch, M. Peppelenbosch   +12 more
semanticscholar   +3 more sources

Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinoma

Biomedical Papers
Aims. The objective of this study was to investigate the association and combined prognostic significance of the PD-L1, Smoothened protein and β-catenin expressions in patients with clear cell renal cell carcinoma (ccRCC). Methods.
Aneta Rozsypalova, Blanka Rosova, Alzbeta Filipova, Dimitar Hadzi Nikolov, Renata Chloupkova, Igor Richter, Roman Zachoval, Radoslav Matej, Bohuslav Melichar, Tomas Buchler, Josef Dvorak   +10 more
doaj   +2 more sources

Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]

PLoS ONE, 2014
Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim, Elaine Y C Hsia, James Kim, Navdar Sever, Philip A Beachy, Xiaoyan Zheng   +5 more
doaj   +3 more sources

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss [PDF]

Advanced Science
Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies.
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
doaj   +2 more sources

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

Nature Communications, 2017
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose
Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu   +20 more
doaj   +2 more sources

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

Molecular Cell, 2017
Xu Xiao, Jing-Jie Tang, Chao Peng
exaly   +2 more sources

Activation mechanism of the human Smoothened receptor

bioRxiv, 2023
Smoothened (SMO) is a membrane protein of the Class F subfamily of G-Protein Coupled Receptors (GPCRs) and maintains homeostasis of cellular differentiation.
Prateek D. Bansal, Soumajit Dutta, D. Shukla   +2 more
semanticscholar   +1 more source

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source