Results 11 to 20 of about 18,655 (253)
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss [PDF]
Advanced ScienceSensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies.
Huanyu Mao +9 more
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Sonic Hedgehog Signaling in Cerebellar Development and Cancer
Frontiers in Cell and Developmental Biology, 2022 The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors.
Wanchen Wang +3 more
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Frontiers in Genetics, 2022 Postaxial polydactyly is a common congenital malformation which involves complex genetic factors. This retrospective study analyzed the cytogenetic and molecular results of a Chinese fetus diagnosed with postaxial polydactyly of all four limbs.
Lihong Fan +6 more
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Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration
Biology, 2021 Glioblastoma (GBM) represents the most common primary brain tumor within the adult population. Current therapeutic options are still limited by high rate of recurrences and signalling axes that promote GBM aggressiveness.
Filippo Torrisi +8 more
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The Secret Life of Smoothened [PDF]
Developmental Cell, 2003 AbstractThe membrane protein Smoothened is the signal-generating component of the Hedgehog pathway. How Smoothened transmits the signal to downstream effectors in the cytoplasm has been a long-standing mystery. Now, with recent reports demonstrating a direct interaction between Smoothened and Costal-2, we appear to be significantly closer to solving ...
Collins, Russell T, Cohen, Stephen M
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Grking the Smoothened signal [PDF]
Science Signaling, 2018 The essential Hedgehog signaling component GRK2 functions at the level of and downstream of Smoothened in both flies and vertebrates (Li et al . and Pusapati et al ., in 6 February 2018 issue).
Hayley J. Sharpe, Frederic J. de Sauvage
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors
Acta Pharmaceutica, 2022 Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in
Fersing Cyril, Mathias Fanny
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Smoothening out the patches [PDF]
Science, 2018 New roles are discovered for cholesterol transport in a key developmental signaling ...
Anselm, Sommer, Mark A, Lemmon
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Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Frontiers in Cell and Developmental Biology, 2022 The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
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Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle
Current Issues in Molecular Biology, 2022 Liver regeneration is a complicated biological process orchestrated by various liver resident cells. Hepatic cell proliferation and reconstruction of the hepatic architecture involve multiple signaling pathways. It has been reported that the Hh signal is
Jiawang Tao +7 more
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