Results 11 to 20 of about 22,572 (280)
Grking the Smoothened signal [PDF]
Science Signaling, 2018 The essential Hedgehog signaling component GRK2 functions at the level of and downstream of Smoothened in both flies and vertebrates (Li et al . and Pusapati et al ., in 6 February 2018 issue).
Frederic J. de Sauvage, Hayley J. Sharpe
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Identification of Novel Smoothened Ligands Using Structure-Based Docking. [PDF]
PLoS ONE, 2016 The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and ...
Celine Lacroix +6 more
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Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease [PDF]
Frontiers in Immunology, 2021 Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have
Diana C. Yánez +7 more
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Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]
PLoS ONE, 2014 Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim +5 more
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Biomedical PapersAims. The objective of this study was to investigate the association and combined prognostic significance of the PD-L1, Smoothened protein and β-catenin expressions in patients with clear cell renal cell carcinoma (ccRCC). Methods.
Aneta Rozsypalova +10 more
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Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling [PDF]
, 2013 Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified.
King, Randall
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Smoothening out the patches [PDF]
Science, 2018 New roles are discovered for cholesterol transport in a key developmental signaling ...
Anselm, Sommer, Mark A, Lemmon
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors
Acta Pharmaceutica, 2022 Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in
Fersing Cyril, Mathias Fanny
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The Secret Life of Smoothened [PDF]
Developmental Cell, 2003 AbstractThe membrane protein Smoothened is the signal-generating component of the Hedgehog pathway. How Smoothened transmits the signal to downstream effectors in the cytoplasm has been a long-standing mystery. Now, with recent reports demonstrating a direct interaction between Smoothened and Costal-2, we appear to be significantly closer to solving ...
Collins, Russell T, Cohen, Stephen M
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Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Frontiers in Cell and Developmental Biology, 2022 The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
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