Results 21 to 30 of about 58,440 (262)
Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo
Pharmaceuticals, 2013 Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma.
Eva Hernando +10 more
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Molecular Pathways: The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2012 AbstractThe Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target pathogenic Hh signaling have steadily progressed from the laboratory to the clinic, and the recent approval of the Hh pathway inhibitor vismodegib for patients with advanced basal cell ...
Ross, McMillan, William, Matsui
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The hedgehog pathway in breast cancer [PDF]
Chinese Journal of Cancer Research, 2012 Breast cancer is one of the most common cancers around the world with approximately 1.6 million new cases and 425 thousand deaths from the disease in 2010 (1). While early detection methods and treatment have continuously evolved and improved over the years, there is still a strong need to further understand the pathways and mechanisms that lead to and
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Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BMC Veterinary Research, 2023 Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
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A highlight on Sonic hedgehog pathway
Cell Communication and Signaling, 2018 Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most of the brain tumors are resistant to chemotherapeutic drugs, consequently, they have a poor
Gabriela Basile Carballo +3 more
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The Hedgehog Signaling Pathway in Ischemic Tissues [PDF]
International Journal of Molecular Sciences, 2019 Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the
Giarretta I. +5 more
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
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Smoothened as a new therapeutic target for human osteosarcoma
Molecular Cancer, 2010 Background The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies.
Nagao Hiroko +7 more
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BMC Research Notes, 2021 Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky +2 more
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Frontiers in GeneticsPurpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog’s role in OA mechanisms is unclear. This study combines Bulk RNA-seq and scRNA-seq to identify Hedgehog-associated genes in OA, investigating their impact on the ...
Tao Wang +7 more
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