Results 21 to 30 of about 55,658 (256)
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP [PDF]
Nature Structural & Molecular Biology, 2009 Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling.
Bishop, Benjamin +5 more
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Hedgehog pathway inhibitors – current status and future prospects
Infectious Agents and Cancer, 2012 The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar +3 more
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Cholesterol modification of Hedgehog family proteins [PDF]
Journal of Clinical Investigation, 2002 The Hedgehog (Hh) gene family encodes a group of secreted signaling molecules that are essential for growth and patterning of many different body parts of vertebrate and invertebrate embryos (1). Depending on the context, Hh signals can promote cell proliferation, prevent apoptosis, or induce specific cell fates.
Jeong, Juhee, McMahon, Andrew P.
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PLoS ONE, 2014 Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat ...
Antonios D Konitsiotis +8 more
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Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]
PLoS ONE, 2014 Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim +5 more
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Canonical Sonic Hedgehog Signaling in Early Lung Development
Journal of Developmental Biology, 2017 The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall,
Hugo Fernandes-Silva +2 more
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Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling [PDF]
Development, 2002 Hedgehog (Hh) signaling plays a major role in multiple aspects of embryonic development, which involves both short- and long-range signaling from localized Hh sources. One unusual aspect of Hh signaling is the autoproteolytic processing of Hh followed by lipid modification.
Takatoshi, Kawakami +5 more
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Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2017 Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu +14 more
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A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. [PDF]
PLoS Genetics, 2011 Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis.
Seongjin Seo +6 more
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Journal of Orthopaedic Surgery and Research, 2021 Objective This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells.
Xinyu Gao +5 more
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