Results 11 to 20 of about 55,658 (256)
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]
Nature Communications, 2021 AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Griffiths, SC +11 more
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The evolutionary origin of hedgehog proteins [PDF]
Current Biology, 2007 SummaryAnimal development is orchestrated largely by diffusible ligands of the Wnt, TGF-β, hedgehog (Hh) and FGF signaling pathways, as well as cell-surface molecules, such as Notch, cadherins, integrins and the immunoglobulin-like proteins [1,2]. Here, we show that Hh proteins are likely to have evolved very early in metazoan evolution by domain ...
Adamska, M. +6 more
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Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review [PDF]
Iranian Journal of Medical SciencesBackground: Some studies have evaluated the manipulation of the sonic hedgehog (Shh) signaling pathway to generate more efficient insulin-producing cells (IPCs).
Dian Dayer, Vahid Bayati, Mina Ebrahimi
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Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. [PDF]
PLoS ONE, 2013 Hedgehog is an evolutionarily conserved developmental pathway, widely implicated in controlling various cellular responses such as cellular proliferation and stem cell renewal in human and other organisms, through external stimuli. Aberrant activation of
Saikat Chowdhury +2 more
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The Hedgehog protein family [PDF]
Genome Biology, 2008 The Hedgehog (Hh) pathway is one of the fundamental signal transduction pathways in animal development and is also involved in stem-cell maintenance and carcinogenesis. The hedgehog (hh) gene was first discovered in Drosophila, and members of the family have since been found in most metazoa.
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Actions of Hedgehog Proteins on Skeletal Cells [PDF]
Critical Reviews in Oral Biology & Medicine, 1999 Recent advances in developmental and molecular biology during embryogenesis and organogenesis have provided new insights into the mechanism of bone formation. Members of the hedgehog gene family were initially characterized as patterning factors in embryonic development, but recently they have been shown to regulate skeletal formation in vertebrates ...
M, Iwamoto +2 more
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PLoS Biology, 2013 Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang +16 more
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Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila
Scientific Reports, 2023 During tissue development, gradients of secreted signaling molecules known as morphogens provide cells with positional information. The mechanisms underlying morphogen spreading have been widely studied, however, it remains largely unexplored whether the
Giulia Pierini, Christian Dahmann
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