Results 11 to 20 of about 92,914 (298)
Crystal Structure of a Hedgehog Autoprocessing Domain: Homology between Hedgehog and Self-Splicing Proteins [PDF]
Cell, 1997 The approximately 25 kDa carboxy-terminal domain of Drosophila Hedgehog protein (Hh-C) possesses an autoprocessing activity that results in an intramolecular cleavage of full-length Hedgehog protein and covalent attachment of a cholesterol moiety to the newly generated amino-terminal fragment.
Hall, Traci M.Tanaka +5 more
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Gli proteins and Hedgehog signaling: development and cancer
Trends in Genetics, 1999 A surprising number of apparently unrelated human diseases, including familial and sporadic cancers and a number of syndromes and malformations, seem to be associated with abnormal function of the Hedgehog (Hh) signaling pathway. Zinc-finger transcription factors of the Gli family play critical roles in the mediation and interpretation of Hh signals ...
Ariel Ruiz i Altaba
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Cholesterol modification of Hedgehog family proteins [PDF]
Journal of Clinical Investigation, 2002 The Hedgehog (Hh) gene family encodes a group of secreted signaling molecules that are essential for growth and patterning of many different body parts of vertebrate and invertebrate embryos (1). Depending on the context, Hh signals can promote cell proliferation, prevent apoptosis, or induce specific cell fates.
Juhee, Jeong, Andrew P, McMahon
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The evolutionary origin of hedgehog proteins [PDF]
Current Biology, 2007 SummaryAnimal development is orchestrated largely by diffusible ligands of the Wnt, TGF-β, hedgehog (Hh) and FGF signaling pathways, as well as cell-surface molecules, such as Notch, cadherins, integrins and the immunoglobulin-like proteins [1,2]. Here, we show that Hh proteins are likely to have evolved very early in metazoan evolution by domain ...
Adamska, M. +6 more
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Hedgehog Signaling Modulates Glial Proteostasis and Lifespan
Cell Reports, 2020 Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis +6 more
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Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP [PDF]
Nature Structural & Molecular Biology, 2009 Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling.
Bishop, Benjamin +5 more
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Hedgehog Signalling in Androgen Independent Prostate Cancer [PDF]
, 2008 Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis.
Bisson, Isabelle +7 more
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Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources