Results 31 to 40 of about 55,434 (254)

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2017
Medulloblastoma is the most common malignant brain tumor in children. Therapeutic approaches to medulloblastoma (combination of surgery, radiotherapy, and chemotherapy) have led to significant improvements, but these are achieved at a high cost to ...
Tao Xu, Honglai Zhang, Sung-Soo Park, Sriram Venneti, Rork Kuick, Kimberly Ha, Lowell Evan Michael, Mariarita Santi, Chiyoko Uchida, Takafumi Uchida, Ashok Srinivasan, James M. Olson, Andrzej A. Dlugosz, Sandra Camelo-Piragua, Jean-François Rual   +14 more
doaj   +1 more source

Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila [PDF]

Current Biology, 1995
The Drosophila segment polarity gene hedgehog encodes a member of a family of secreted proteins that are involved in a variety of patterning processes, in both vertebrates and invertebrates. Some of these processes depend upon short-range or contact-dependent interactions, whereas others seem to involve long-range signalling.
Fietz, M.J., Jacinto, A., Taylor, A.M., Alexandre, C., Ingham, P.W.   +4 more
openaire   +2 more sources

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. [PDF]

PLoS Genetics, 2011
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis.
Seongjin Seo, Qihong Zhang, Kevin Bugge, David K Breslow, Charles C Searby, Maxence V Nachury, Val C Sheffield   +6 more
doaj   +1 more source

Induction of Osteogenic Differentiation by Hedgehog Proteins

Biochemical and Biophysical Research Communications, 1997
In this study we asked whether members of the hedgehog gene family are involved in osteogenesis. C3H10T1/2 cells and MC3T3-E1 cells expressed the putative hedgehog receptor patched (Ptc) gene. Medium conditioned by chicken embryo fibroblast cultures expressing either Indian hedgehog or Sonic hedgehog stimulated alkaline phosphatase (APase) activity in ...
T, Nakamura, T, Aikawa, M, Iwamoto-Enomoto, M, Iwamoto, Y, Higuchi, M, Pacifici, N, Kinto, A, Yamaguchi, S, Noji, K, Kurisu, T, Matsuya, P, Maurizio   +11 more
openaire   +2 more sources

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum [PDF]

Journal of Cell Biology, 2011
The Hedgehog (Hh) signaling pathway has important functions during metazoan development. The Hh ligand is generated from a precursor by self-cleavage, which requires a free cysteine in the C-terminal part of the protein and results in the production of the cholesterol-modified ligand and a C-terminal fragment.
Chen, Xin, Tukachinsky, Hanna, Huang, Chih-Hsiang, Jao, Cindy, Chu, Yue-Ru, Tang, Hsiang-Yun, Mueller, Britta, Schulman, Sol, Rapoport, Tom A., Salic, Adrian   +9 more
openaire   +4 more sources

Mechanism of exosomal miR-155 derived from bone marrow mesenchymal stem cells on stemness maintenance and drug resistance in myeloma cells

Journal of Orthopaedic Surgery and Research, 2021
Objective This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells.
Xinyu Gao, Jin Zhou, Jinghua Wang, Xiushuai Dong, Yuying Chang, Yinglan Jin   +5 more
doaj   +1 more source

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +12 more
doaj   +1 more source

Intein Inhibitors as Novel Antimicrobials: Protein Splicing in Human Pathogens, Screening Methods, and Off-Target Considerations

Frontiers in Molecular Biosciences, 2021
Protein splicing is a post-translational process by which an intervening polypeptide, or intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with extein ligation. Although inteins are highly abundant in the microbial
Diana A. Wall, Seanan P. Tarrant, Chunyu Wang, Chunyu Wang, Kenneth V. Mills, Christopher W. Lennon   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

RETRACTED: TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

Thoracic Cancer, 2021
Background Transmembrane protein 107 (TMEM107) is a key regulator of the cilium composition and Hedgehog signaling. Lower TMEM107 gene copies are correlated with poor prognosis in non‐small cell lung carcinoma (NSCLC). However, TMEM107 protein expression,
Huihui Xu, Song Dun, Ying Gao, Jian Ming, Linping Hui, Xueshan Qiu   +5 more
doaj   +1 more source