Results 61 to 70 of about 74,513 (285)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies [PDF]

European Cells & Materials, 2011
The morphogen sonic hedgehog (Shh) seems to mediate adult repair processes in bone regeneration and vascularisation. In this study we investigated the effects of Shh on co-cultures consisting of human primary osteoblasts and outgrowth endothelial cells ...
CJ Kirkpatrick, A Hofmann, H Schmidt, S Fuchs, M Kolbe, E Dohle   +5 more
doaj  

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

Cell Reports, 2018
Summary: Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC progenitors during embryogenesis before Shh production by Purkinje neurons and their ...
Issei S. Shimada, Sun-Hee Hwang, Bandarigoda N. Somatilaka, Xin Wang, Patryk Skowron, Jiwoong Kim, Min Kim, John M. Shelton, Veena Rajaram, Zhenyu Xuan, Michael D. Taylor, Saikat Mukhopadhyay   +11 more
doaj   +1 more source

An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression [PDF]

Journal of Clinical Investigation, 2005
Short digits (Dsh) is a radiation-induced mouse mutant. Homozygous mice are characterized by multiple defects strongly resembling those resulting from Sonic hedgehog (Shh) inactivation. Heterozygous mice show a limb reduction phenotype with fusion and shortening of the proximal and middle phalanges in all digits, similar to human brachydactyly type A1,
Michael, Niedermaier, Georg C, Schwabe, Stephan, Fees, Anne, Helmrich, Norbert, Brieske, Petra, Seemann, Jochen, Hecht, Volkhard, Seitz, Sigmar, Stricker, Gundula, Leschik, Evelin, Schrock, Paul B, Selby, Stefan, Mundlos   +12 more
openaire   +2 more sources

Shh critically mediates cholangiocyte differentiation.

, 2016
A. Reduced Shh dosing reduces mRNA levels of CK7, CK19, and FN (++Shh = 100 ng/ml Shh administered for 8 days, +Shh = 100 ng/ml Shh administered for 4 days, -Shh = no Shh administration). B.
Thiago M. De Assuncao (3391997), Luciana L. Almada (119627), Raul Urrutia (1537), Gwen Lomberk (23718), Nidhi Jalan-Sakrikar (1347150), Robert C. Huebert (3392000), Martin E. Fernandez-Zapico (119657), Jie Lu (139953)   +7 more
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets

eLife, 2015
Dentate neural stem cells produce neurons throughout life in mammals. Sonic hedgehog (Shh) is critical for maintenance of these cells; however, the perinatal source of Shh is enigmatic.
Youngshik Choe, Trung Huynh, Samuel J Pleasure   +2 more
doaj   +1 more source

Evasion of cell senescence in SHH medulloblastoma [PDF]

Cell Cycle, 2016
The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1+/- mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event associated with cell senescence in preneoplasia ...
Tamayo-Orrego, Lukas; id_orcid 0000-0001-7041-4848, Swikert, Shannon M., Charron, Frédéric   +2 more
openaire   +3 more sources

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Shh Phosphatome Screen

, 2015
Table 1-Phosphatome Screen-Shh Signaling.  The individual genes tested in primary screen for phosphatases involved in Shh signaling.  Gene symbol, gene name and identifier and the target sequence are shown.
Rosalind Segal (682740), Adriana Eisner (683040)   +1 more
core   +1 more source