Results 81 to 90 of about 79,021 (275)

The Effects of FGF8 and Shh on Expression of Dopaminergic Markers from Human Amniotic Epithelial Cells

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2011
Background and Objectives: Recently, interest has increased in the potential employment of embryonic stem cells for the treatment of Parkinsonchr('39')s disease, which has been considered as an alternative therapeutic strategy.
H Niknejad, H Peirovi, A Ahmadian, M Jorjani   +3 more
doaj  

Synthese von Aminocyclopropanen durch redoxneutrale Aminoalkylierung

Angewandte Chemie, EarlyView.
Wir berichten über eine Synthese von Aminocyclopropanen durch Hydroaminoalkylierung unter Einsatz kostengünstiger, leicht zugänglicher Ausgangsmaterialien. Der Ansatz bietet Orthogonalität zu gängigen Methoden und ermöglicht eine breite Toleranz gegenüber funktionellen Gruppen.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

CMA‐mediated USP9X degradation promotes SHH medulloblastoma progression by facilitating SUFU ubiquitination

Clinical and Translational Medicine
Background Medulloblastoma (MB) represents the most prevalent malignant paediatric brain tumour, characterised by the sonic Hedgehog molecular subtype (SHH‐MB), which is driven by aberrant activation of the SHH signalling cascade.
Binbin Gao, Qin Zhu, Lun Kuang, Jiahui Li, Qingyue Meng, Bo'ang Han, Yu Wang, Xinyi Zhang, Xiangxiang Zhang, Xinfa Wang, Tingting Yu, Shen Yue, Chen Liu   +12 more
doaj   +1 more source

Sonic hedgehog protein is decreased and penile morphology is altered in prostatectomy and diabetic patients.

PLoS ONE, 2013
Erectile dysfunction (ED) is a debilitating medical condition and current treatments are ineffective in patients with cavernous nerve (CN) injury, due to penile remodeling and apoptosis.
Nicholas L Angeloni, Christopher W Bond, Kevin T McVary, Carol A Podlasek   +3 more
doaj   +1 more source

Shh upregulates the Shh signaling pathway and multiple cytokines in Shh transfected chondrocytes.

, 2014
To explore potential mechanisms responsible for the redifferentiation effect of Shh, we evaluated the Shh signaling pathway. Real time RT-PCR and western blot analysis verified the stronger expression of Ptc1, Gli1 and Sox9 in Shh transfected cells after
Changlong Yu (522580), Lin Lin (46073), Qi Shen (166827), Xin Fu (448766), Xiaoning Duan (522579), Tao Xue (488854)   +5 more
core   +1 more source

Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation

Angewandte Chemie International Edition, EarlyView.
Aminocyclopropane synthesis by hydroaminoalkylation utilizing cheap, readily available starting materials is presented, offering orthogonality to commonly used methods and allowing broad functional‐group tolerance. Solvent‐mediated conditions enable the reaction of a pre‐formed hemiaminal with alkenes and alkynes.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

Gonadal development in scorpion mud‐turtles, Kinosternon scorpioides, in a controlled environment

The Anatomical Record, EarlyView.
Stage 20 was identified as the critical point for gonadal differentiation in Kinosternon scorpioides, providing key insights into sex determination. These findings enhance conservation strategies by supporting reproductive management and population viability in both in situ and ex situ programs. Abstract Research on gonadal development including sexual
Brenda Braga, Verônica Oliveira‐Bahia, Maria Auxiliadora Ferreira, José Ribamar Felipe Marques, Diva Araújo Guimarães   +4 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source