Results 91 to 100 of about 74,513 (285)
British Educational Research Journal, EarlyView.Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley +1 more source
Effect of SHH interruption on cerebellar development
, 2018 During development, disruptions in sonic hedgehog (SHH) signaling can lead to medulloblastoma, the most common malignant pediatric brain tumor. Medulloblastoma tumor cells arise from cerebellar granule neural progenitors (CGNPs), which rely on SHH ...
Rapp, Carolyn
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Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
, 2007 TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E +7 more
core
Shh Treatment Preserves BBB permeability.
, 2013 After establishment of pMCAO, rats were intracerebroventricularly injected 3 µL of PBS, 3 µg of Shh, and Shh (3 µg) plus cyclopamine (Cyc, 30 µg). The BBB permeability was detected by Evans Blue extravasation at indicated time points (1 d, 3 d, and 7 d).
Yan Huang (46805) +10 more
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Loss, persistence and reversal of phenotypic traits
Biological Reviews, EarlyView.ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
wiley +1 more source
Shh expression in vivo. In non-transfected group, Shh expression was not detected (A).
, 2014 In the defects in Shh group, the repair tissues contained Shh protein proved by immunohistochemical staining 2 weeks after transplantation (B). In the negative control without primary antibody, Shh expression was not detected (data not shown).
Changlong Yu (522580) +5 more
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Developmental Dynamics, EarlyView.Abstract Background Dentitions have diversified enormously during vertebrate evolution, involving reductions, modifications, or allocations to prey seizing and processing regions. A combination of ancient and novel features related to dental and oropharyngeal apparatuses is found in extant lineages of non‐teleost fishes, such as the gars.
Anna Pospisilova +4 more
wiley +1 more source
Frontiers in Immunology, 2018 Activation and reprogramming of hematopoietic stem/progenitor cells play a critical role in the granulopoietic response to bacterial infection. Our current study determined the significance of Sonic hedgehog (SHH) signaling in the regulation of ...
Xin Shi +5 more
doaj +1 more source
Identification of novel genes regulating the development of the palate
Developmental Dynamics, EarlyView.Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley +1 more source