Results 101 to 110 of about 74,513 (285)

Secondary receptors of the Shh pathway [PDF]

, 2015
The Sonic Hedgehog signaling pathway is central in vertebrate development and in several human disease states. Our current understanding of the pathway outlines a straight-forward mechanism whereby the Shh ligand is perceived by the nine-pass ...
Alfaro, Astrid Carolina
core  

Biophysical processes of morphogenesis in lizard lungs

Developmental Dynamics, EarlyView.
Abstract Background The lungs of squamate reptiles (lizards and snakes) are highly diverse, exhibiting single chambers, multiple chambers, transitional forms with two to three chambers, along with a suite of other anatomical features, including finger‐like epithelial projections into the body cavity known as diverticulae.
Kaleb Hill, Aaron H. Griffing, Michael A. Palmer, Bezia Lemma, Aria S. Lupo, Tony Gamble, Natalia A. Shylo, Andrej Košmrlj, Paul A. Trainor, Celeste M. Nelson   +9 more
wiley   +1 more source

Sonic hedgehog improves redifferentiation of dedifferentiated chondrocytes for articular cartilage repair.

PLoS ONE, 2014
Sonic hedgehog (Shh) is involved in the induction of early cartilaginous differentiation of mesenchymal cells in the limb. We investigated whether Shh could promote redifferentiation of dedifferentiated chondrocytes and have a favorable effect on the ...
Lin Lin, Qi Shen, Tao Xue, Xiaoning Duan, Xin Fu, Changlong Yu   +5 more
doaj   +1 more source

Shh Treatment Ameliorates the Brain Edema.

, 2013
After establishment of pMCAO, rats were intracerebroventricularly injected 3 µL of PBS, 3 µg of Shh, and Shh (3 µg) plus cyclopamine (Cyc, 30 µg). The brain edema was detected by water content measurement at indicated time points (1 d, 3 d, and 7 d). The
Yan Huang (46805), Yuan Gao (159945), Quan-wei He (436443), Bo Hu (126105), Ya-nan Li (300741), Ming Huang (301457), Meng-die Wang (436445), Yuan-peng Xia (5655769), Yong Wang (12837), Sheng-cai Chen (436444), Ling Mao (145467)   +10 more
core   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Sonic hedgehog promotes autophagy in hippocampal neurons

Biology Open, 2013
Summary The Sonic hedgehog (Shh) signaling pathway is well known in patterning of the neural tube during embryonic development, but its emerging role in differentiated neurons is less understood.
Ronald S. Petralia, Catherine M. Schwartz, Ya-Xian Wang, Elisa M. Kawamoto, Mark P. Mattson, Pamela J. Yao   +5 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth

Scientific Reports
Medulloblastoma constitutes a molecularly diverse group of malignant embryonal brain tumors. Sonic hedgehog molecular group of medulloblastoma (SHH-MB) is a highly heterogeneous tumor entity, characterized by constitutive activation of the SHH signaling ...
Foteini Tsiami, Layla Drwesh, Surender Surender, Julia Fitzgerald, Jens Schittenhelm, David J. Picketts, Rosalind A. Segal, Ghazaleh Tabatabai, Daniel J. Merk   +8 more
doaj   +1 more source

Shh induces tectal NSC proliferation.

, 2013
Nsp suspension cultures were immobilized in collagen type-I gels. Proliferation experiments were performed for 8 hours and included a BrdU (1 µg/ml) pulse for the last 2 hours in the presence of EGF and FGF-2 (used at 1 ng/ml or 10 ng/ml); combined with ...
Constanza Martínez (420465), Verónica Palma (420469), Víctor Hugo Cornejo (420466), Brandon J. Wainwright (229991), Pablo Lois (420467), Natalia P. Solis (420468), Tammy Ellis (229977)   +6 more
core   +1 more source

Optimisation of Electrokinetic Extraction System: Colourimetric Determination of Copper (II) in Sand Using Polymer Inclusion Membrane

ELECTROPHORESIS, EarlyView.
Electrokinetic extraction (EKE) allows the direct transfer of heavy metals from soli samples, such as soil and sediment, into a polymer inclusion membrane (PIM) with a colourimetric detection. This avoids length and complex sampling handling and extraction processes.
Jia Jia Seet, Spas D. Kolev, Rosanne Guijt, Hong Heng See, Fernando Maya, Mostafa A. Atia, Eddie A. Nagul, Owen P. Missen, Michael Breadmore   +8 more
wiley   +1 more source