Results 121 to 130 of about 74,513 (285)
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2013 目的构建人Shh基因过表达慢病毒载体,转染293T细胞,建立稳定转染人Shh基因的293T的细胞系。方法设计引物引入AgeⅠ酶切位点,使用PCR方法从质粒中扩增Shh基因的编码区序列,对所扩增出的目的片段回收纯化。将AgeⅠ内切酶消化后目的片段交换连接入pGC-FU载体,构建Shh慢病毒表达载体pGC-FU-Shh。酶切验证并测序正确后,将质粒pGC-FU-Shh与携带GFP的慢病毒辅助包装载体共转染293T细胞,荧光显微镜检测慢病毒载体转染细胞的结果,重组质粒pGC-FU-Shh的测序,Western
边学海 +6 more
doaj
Population MedicineIntroduction The aim of the study was to assess the prevalence and associated factors of hand hygiene (HH) and oral hygiene (OH) behavior in adolescents in Central America.
Supa Pengpid, Karl Peltzer
doaj +1 more source
, 2007 PhDEmbryonic development is regulated by a number of signalling pathways, Which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult.
Ikram, Mohammed S, Ikram, Mohammed. S.
core
Ptch2 mediates the Shh response in Ptch1(-/-) cells
, 2014 The Hedgehog (Hh) signaling response is regulated by the interaction of three key components that include the sonic hedgehog (Shh) ligand, its receptor patched 1 (Ptch1) and the pathway activator smoothened (Smo).
Bijlsma, Maarten F. +4 more
core +1 more source
Sleep Research, EarlyView.Abstract Study Objectives Obesity is a major determinant of obstructive sleep apnea (OSA) severity, but its influence may vary across adulthood. We examined age‐related patterns of body mass index (BMI), apnea–hypopnea index (AHI), and hypoxemic burden, and assessed whether the association between BMI and OSA severity attenuates with age.
Peretz Lavie
wiley +1 more source
The Journal of Cell Biology, 2004 Cells in the developing limb escape a positive feedback loop by growing a nonresponsive barrier of cells. This timing mechanism that limits both limb size and digit number is described by Paul Scherz, Clifford Tabin (Harvard Medical School, Boston, MA), and colleagues.
openaire +2 more sources
Shh overexpression exacerbates Helicobacter gastritis.
, 2013 A) H&E staining of NTG, CMV-ShhWT and CMV-ShhF200H mouse stomachs. Arrows indicate regions of inflammatory cell infiltration and mucous neck cell expansion, SPEM. B) Polymorphonuclear (PMN) cell scoring in NTG and CMV-ShhWT mice.
Michael M. Hayes (387426) +7 more
core +1 more source
Small, EarlyView.A microfluidic model of the glioblastoma (GBM) margin was developed to mimic patient‐specific blood‐brain tumor barrier (BBTB) function and drug response. The platform revealed inter‐patient variability in barrier integrity and drug sensitivity, offering a tool for personalized therapy evaluation in GBM.
Minsu Ryoo +16 more
wiley +1 more source
Small, EarlyView.We present a pathology‐responsive, activity‐based prodrug strategy that tackles multiple hallmarks of Alzheimer's disease (AD). Rationally designed BE compounds convert under oxidative stress into redox‐active aminophenols, neutralizing ROS and redirecting both metal‐free and metal‐bound Aβ aggregation.
Jimin Lee +13 more
wiley +1 more source