Results 141 to 150 of about 74,513 (285)

Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol‐Stimulating Tests are Safe and Often Required

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction The accuracy and safety of cortisol‐stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study ...
Mariana Peduti Halah, Ana Carolina Maia Teodózio, Davi Casale Aragon, Paula Conde Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Rauber Antonini   +6 more
wiley   +1 more source

Shh hypomorph mouse embryo E17.5

, 2018
Shh hypomorph mouse embryo analyzed at embryonic day E17.
Kazunori Sunadome (5396135), Bara Szarowska (5396156), Leslie Pan (5396126), Maria Eleni Kastriti (5396162), Karl Annusver (5396129), Francois Spitz (5396147), Jozef Kaiser (5396144), Kaj Fried (5396138), Julian Petersen (5396132), Patrik Ernfors (3108603), Ulrika Marklund (5396159), Orsolya Symmons (5396150), Tomas Zikmund (519148), Marketa Tesarova (5396123), Meng Xie (501184), Anna Kicheva (248020), Igor Adameyko (5396141), Maria Hovorakova (3111099), Hui Wang (30400), Marketa Kaucka (167847), Andrei S. Chagin (428691), Hind Abdo (5396153), Pascal Maire (407254), Maud Wurmser (3447275), Maria Kasper (4578178), Michael P. Matise (3138426)   +25 more
core   +1 more source

Shh promotes proliferation and maintenance of RGCs.

, 2013
Differentiation experiments were performed during 14 days without addition of EGF or FGF-2. (A) Representative images of immunostaining for Blbp after control or Shh treatment. Close-up view of a RGC stained for Blbp treated with Shh. Bar, 20 µm.
Constanza Martínez (420465), Verónica Palma (420469), Víctor Hugo Cornejo (420466), Brandon J. Wainwright (229991), Pablo Lois (420467), Natalia P. Solis (420468), Tammy Ellis (229977)   +6 more
core   +1 more source

Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid

Cell Proliferation, EarlyView.
By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu   +10 more
wiley   +1 more source

Shh signaling in limb development

, 2013
Sonic hedgehog (Shh), a secreted signaling molecule, is generated from the posterior limb margin and essential in regulating anterior-posterior (A-P) patterning as well as growth and differentiation of limb mesenchyme.
Liu, Jiang
core  

Duration of Shh signaling contributes to mDA neuron diversity

, 2013
Sonic hedgehog (Shh) signaling is critical for various developmental processes including specification of the midbrain dopamine (mDA) neurons in the ventral mesencephalon (vMes).
Ralls, Sherry, Hayes, Lindsay, Wang, Hui, Ahn, Sohyun   +3 more
core   +1 more source

Unveiling the molecular profile of adenosquamous gallbladder carcinoma: characterization of a Caucasian cohort

Histopathology, EarlyView.
GBASCs are MMRp tumours, exhibiting minimal HER2 overexpression and elevated PD‐L1 expression compared to adenocarcinomas. Especially in metastatic and TP53‐wild type tumours, GBASCs can express CLDN18, albeit limited to the glandular component. Their genomic profile resembles that of adenocarcinomas with an enrichment in alterations on PIK3CA, PTEN ...
Jessica Gasparello, Valentina Angerilli, Mario Domenico Rizzato, Edoardo Maffii, Carlotta Ceccon, Matilde Callegarin, Marianna Sabbadin, Monia Niero, Luisa Toffolatti, Francesca Bergamo, Paola Parente, Luca Mastracci, Federica Grillo, Alessandro Vanoli, Paola Mattiolo, Claudio Luchini, Angelo Paolo Dei Tos, Umberto Cillo, Giacomo Zanus, Sara Lonardi, Matteo Fassan   +20 more
wiley   +1 more source

Shh hypomorph mouse embryo E15.5

, 2018
Shh hypomorph mouse embryo analyzed at embryonic day E15.
Kazunori Sunadome (5396135), Bara Szarowska (5396156), Leslie Pan (5396126), Maria Eleni Kastriti (5396162), Karl Annusver (5396129), Francois Spitz (5396147), Jozef Kaiser (5396144), Kaj Fried (5396138), Julian Petersen (5396132), Patrik Ernfors (3108603), Ulrika Marklund (5396159), Orsolya Symmons (5396150), Tomas Zikmund (519148), Marketa Tesarova (5396123), Meng Xie (501184), Anna Kicheva (248020), Igor Adameyko (5396141), Maria Hovorakova (3111099), Hui Wang (30400), Marketa Kaucka (167847), Andrei S. Chagin (428691), Hind Abdo (5396153), Pascal Maire (407254), Maud Wurmser (3447275), Maria Kasper (4578178), Michael P. Matise (3138426)   +25 more
core   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling pathway characterizes two of these molecular subgroups, the former associated with low-
Dalton J, Neale G, Taylor RE, Gilbertson RJ, Ellison DW, Kocak M, Brat DJ, Perry A, Fraga C, Bailey S, Kenney AM, Yong WH, Nicholson SL, Clifford SC   +13 more
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