Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infraorbital blood–nerve barrier following chronic constriction injury? [PDF]
Molecular Pain, 2017 Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau +7 more
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Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction [PDF]
Neural Regeneration ResearchRecent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen +16 more
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Sonic Hedgehog Signaling in Thyroid Cancer [PDF]
Frontiers in Endocrinology, 2017 Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS ...
Xiulong Xu +4 more
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Probing extracellular Sonic hedgehog in neurons [PDF]
Biology Open, 2016 The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in ...
Erez Eitan +5 more
doaj +3 more sources
A highlight on Sonic hedgehog pathway
Cell Communication and Signaling, 2018 Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of ...
Gabriela Basile Carballo +3 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]
, 2016 Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H +4 more
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Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
Biomedicines, 2022 Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan +2 more
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Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]
Open Biology, 2021 Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
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