Results 11 to 20 of about 37,487 (203)
Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights [PDF]
Neural Regeneration ResearchOver the past few decades, the Sonic Hedgehog protein has become a pivotal player in many biological processes, including tumourigenesis, embryonic development, and protective mechanisms after cerebral damage.
Nuokun Li +11 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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Sonic Hedgehog activation is implicated in diosgenin-induced megakaryocytic differentiation of human erythroleukemia cells. [PDF]
PLoS ONE, 2014 Differentiation therapy is a means to treat cancer and is induced by different agents with low toxicity and more specificity than traditional ones. Diosgenin, a plant steroid, is able to induce megakaryocytic differentiation or apoptosis in human HEL ...
Lamia Ghezali +4 more
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A Notch above Sonic Hedgehog [PDF]
Developmental Cell, 2015 Cell fate specification requires tightly orchestrated cellular responses to extracellular factors. In this issue of Developmental Cell, Kong et al. (2015) reveal that Notch signaling activity facilitates the interpretation of Sonic hedgehog (Shh) signals by regulating signaling in the cilia, influencing fate specification of neural stem and progenitor ...
Yabut, Odessa +2 more
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Sonic hedgehog: making the gradient
Chemistry & Biology, 1996 The amino-terminal peptide of Sonic hedgehog is a cell-tethered molecule, which nevertheless seems to provide a developmental signal that acts at a distance and has different effects depending on its concentration. Recent structural data suggest that zinc-dependent proteolysis may somehow be involved in Sonic hedgehog's function.
Bumcrot, David A., McMahon, Andrew P.
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.
Magnaldo, T
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Sonic hedgehog pathway expression in non-small cell lung cancer
Therapeutic Advances in Medical Oncology, 2012 Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani +2 more
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A highlight on Sonic hedgehog pathway
Cell Communication and Signaling, 2018 Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of ...
Gabriela Basile Carballo +3 more
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Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction [PDF]
Neural Regeneration ResearchRecent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen +16 more
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Atorvastatin blocks Sonic Hedgehog medulloblastoma progression through apoptosis
Учёные записки Казанского университета: Серия Естественные науки, 2017 Aberrant activation of Sonic Hedgehog signaling transduction leads to formation of numerous malignancies, including medulloblastoma (MB) – the most common malignant pediatric tumor.
R.E. Gordon, Z.I. Abramova
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