Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
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Sonic Hedgehog Signaling and VACTERL Association [PDF]
Molecular Syndromology, 2012 Hedgehog (Hh) signaling is vital for the patterning and organogenesis of almost every system. The specificity of these developmental processes is achieved through a tight spatio-temporal regulation of Hh signaling. Mice with defective Hh signal exhibit a wide spectrum of anomalies, including Vertebral defects, Anal atresia, Cardiovascular anomalies ...
Kim, KH, Hui, CC, Ngan, ESW
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Tobacco Induced Diseases, 2019 Introduction Many studies have shown that COPD is associated with apoptosis of bronchial or alveolar epithelial cells. Alveolar type II epithelial cells (AECII) play an important role in the pathogenetic process.
Jinhua Li +3 more
doaj +1 more source
Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling [PDF]
, 2015 Background: Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity.
G., Barsacchi +5 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on SHH (Sonic hedgehog), with data on DNA, on the protein encoded, and where the gene is implicated.
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Frontiers in Cellular and Infection Microbiology, 2022 ObjectivesTo investigate the pathogenic effect of Porphyromonas gingivalis cultured media on the esophagus and the mechanism underlying the effect.BackgroundPeriodontitis is strongly associated with esophageal squamous cell carcinoma (ESCC). The cultured
Xueting Jia +7 more
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Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway [PDF]
, 2017 Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (GCPs) and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma.
BELLAVIA, Diana +13 more
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Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats
Molecular Pain, 2018 Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain.
Su Liu +7 more
doaj +1 more source
Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation. [PDF]
PLoS ONE, 2015 Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic
Frederique Zindy +7 more
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Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis [PDF]
, 2017 Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized ...
Brilha, Sara +5 more
core +3 more sources