Results 31 to 40 of about 116,918 (241)
Widespread contribution of Gdf7 lineage to cerebellar cell types and implications for hedgehog-driven medulloblastoma formation. [PDF]
PLoS ONE, 2012 The roof plate is a specialized embryonic midline tissue of the central nervous system that functions as a signaling center regulating dorsal neural patterning.
Frances Y Cheng +6 more
doaj +1 more source
Sonic Hedgehog Signaling and VACTERL Association [PDF]
Molecular Syndromology, 2012 Hedgehog (Hh) signaling is vital for the patterning and organogenesis of almost every system. The specificity of these developmental processes is achieved through a tight spatio-temporal regulation of Hh signaling. Mice with defective Hh signal exhibit a wide spectrum of anomalies, including Vertebral defects, Anal atresia, Cardiovascular anomalies ...
Kim, KH, Hui, CC, Ngan, ESW
openaire +3 more sources
Gli1 mediates lung cancer cell proliferation and sonic hedgehog-dependent mesenchymal cell activation. [PDF]
, 2013 Non-Small-Cell-Lung-Cancer (NSCLC) represents approximately 85% of all lung cancers and remains poorly understood. While signaling pathways operative during organ development, including Sonic Hedgehog (Shh) and associated Gli transcription factors (Gli1 ...
Hennen, Elisabeth +19 more
core +2 more sources
Tobacco Induced Diseases, 2019 Introduction Many studies have shown that COPD is associated with apoptosis of bronchial or alveolar epithelial cells. Alveolar type II epithelial cells (AECII) play an important role in the pathogenetic process.
Jinhua Li +3 more
doaj +1 more source
Nature Communications, 2021 Dispatched (Disp) RND transporter, activated by Furin-mediated proteolytic cleavage, mediates the release of the lipid-modified Hedgehog (Hh) ligands. Here, the authors report structures of human Disp1 (hDisp1) before and after cleavage, and in complex ...
Wanqiu Li +9 more
doaj +1 more source
Molecular Pain, 2017 Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau +7 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats
Molecular Pain, 2018 Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain.
Su Liu +7 more
doaj +1 more source
Sonic Hedgehog, Apoptosis, and the Penis [PDF]
The Journal of Sexual Medicine, 2009 ABSTRACT Introduction Smooth muscle apoptosis in the penis is common in prostatectomy patients and animal models of erectile dysfunction (ED). A critical regulator of smooth muscle apoptosis in the penis is the secreted protein Sonic hedgehog (SHH).
openaire +2 more sources
Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]
, 2009 We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V +17 more
core +1 more source