Results 21 to 30 of about 116,918 (241)

Sonic hedgehog specifies flight feather positional information in avian wings [PDF]

, 2023
Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers.
McQueen, Caitlin, Busby, Lara, Rich, Constance, Towers, Matthew, Aceituno, Cristina, Ros, Maria   +5 more
core   +1 more source

A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance

Hepatology Communications, EarlyView., 2022
Abstract Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed.
Martijn P. D. Haring, Arthur K. E. Elfrink, Christiaan A. J. Oudmaijer, Paul C. M. Andel, Alicia Furumaya, Nenke de Jong, Colin J. J. M. Willems, Thijs Huits, Julie M. L. Sijmons, Eric J. T. Belt, Koop Bosscha, Esther C. J. Consten, Mariëlle M. E. Coolsen, Peter van Duijvendijk, Joris I. Erdmann, Paul Gobardhan, Robbert J. de Haas, Tjarda van Heek, Hwai‐Ding Lam, Wouter K. G. Leclercq, Mike S. L. Liem, Hendrik A. Marsman, Gijs A. Patijn, Türkan Terkivatan, Babs M. Zonderhuis, Izaak Quintus Molenaar, Wouter W. te Riele, Jeroen Hagendoorn, Alexander F. M. Schaapherder, Jan N. M. IJzermans, Carlijn I. Buis, Joost M. Klaase, Koert P. de Jong, Vincent E. de Meijer, the Dutch Benign Liver Tumor Group, R. B. Takkenberg, J. Verheij, O. M. van Delden, J. I. Erdmann, B. V. van Rosmalen, A. Furumaya, G. Kazemier, D. Ramsoekh, J. N. M. IJzermans, R. A. de Man, M. D. Doukas, M. G. Thomeer, A. J. Klompenhouwer, A. F. M. Schaapherder, M. E. Tushuizen, M. J. Coenraad, A. S. L. P. Crobach, M. C. Burgmans, S. Feshtali, M. M. E. Coolsen, M. Kramer, J. C. Beckervordersandforth, I. V. Samarska, C. van der Leij, R. Miclea, J. H. W. de Wilt, P. B. van den Boezem, E. T. T. L. Tjwa, I. Munsterman, S. Vos, S. van Koeverden, V. E. de Meijer, F. J. C. Cuperus, R. J. de Haas, E. W. Duiker, M. P. D. Haring   +70 more
wiley   +1 more source

A Notch above Sonic Hedgehog [PDF]

Developmental Cell, 2015
Cell fate specification requires tightly orchestrated cellular responses to extracellular factors. In this issue of Developmental Cell, Kong et al. (2015) reveal that Notch signaling activity facilitates the interpretation of Sonic hedgehog (Shh) signals by regulating signaling in the cilia, influencing fate specification of neural stem and progenitor ...
Yabut, Odessa, Pleasure, Samuel J., Yoon, Keejung   +2 more
openaire   +2 more sources

Sonic Hedgehog in SCLC

Aging, 2015
The Hedgehog (Hh) signal transduction pathway has been discovered as a central regulator of embryonic development, tissue maintenance and repair [1]. Moreover, several recent evidences have highlighted its key function in tumorigenesis [2]. In some familial cancers, such as basal cell carcinoma and medulloblastoma, Hh pathway activation represents the ...
Laukkanen M, Gutkind J, Castellone M
openaire   +5 more sources

Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M., Chapple, JP, Chapple, J.P., Knight, MM, Thompson, CL, Thompson, C.L.   +5 more
core   +3 more sources

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]

Nature Chemical Biology, 2013
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta, Rios-Esteves, Jessica, Ouerfelli, Ouathek, Glickman, J. Fraser, Resh, Marilyn D.   +4 more
openaire   +2 more sources

The role of primary cilia and sonic hedgehog signalling in adrenal development function. [PDF]

, 2012
PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core   +4 more sources

The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study

Frontiers in Chemistry, 2017
Erroneous activation of the Hedgehog pathway has been linked to a great amount of cancerous diseases and therefore a large number of studies aiming at its inhibition have been carried out. One leverage point for novel therapeutic strategies targeting the
Manuel Hitzenberger, Manuel Hitzenberger, Daniela Schuster, Thomas S. Hofer   +3 more
doaj   +1 more source

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

Nature Communications, 2021
Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights into ...
Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold   +11 more
doaj   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Flinspach, Armin Niklas, Wenger, Florian, Warzecha, Jörg   +5 more
core   +1 more source