Results 21 to 30 of about 37,487 (203)
Probing extracellular Sonic hedgehog in neurons [PDF]
Biology Open, 2016 The bioactivity of Sonic hedgehog (Shh) depends on specific lipid modifications; a palmitate at its N-terminus and a cholesterol at its C-terminus. This dual-lipid modification makes Shh molecules lipophilic, which prevents them from diffusing freely in ...
Erez Eitan +5 more
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Sonic Hedgehog Signaling in Thyroid Cancer [PDF]
Frontiers in Endocrinology, 2017 Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS ...
Xiulong Xu +4 more
doaj +3 more sources
Sonic hedgehog specifies flight feather positional information in avian wings [PDF]
, 2023 Classical tissue recombination experiments performed in the chick embryo provide evidence that signals operating during early limb development specify the position and identity of feathers.
McQueen, Caitlin +5 more
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Sonic hedgehog signaling in astrocytes [PDF]
Cellular and Molecular Life Sciences, 2020 AbstractAstrocytes are complex cells that perform a broad array of essential functions in the healthy and injured nervous system. The recognition that these cells are integral components of various processes, including synapse formation, modulation of synaptic activity, and response to injury, underscores the need to identify the molecular signaling ...
Steven A. Hill +2 more
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Ethanol Effects on Early Developmental Stages Studied Using the Zebrafish
Biomedicines, 2022 Fetal alcohol spectrum disorder (FASD) results from prenatal ethanol exposure. The zebrafish (Danio rerio) is an outstanding in vivo FASD model. Early development produced the three germ layers and embryonic axes patterning.
Priyadharshini Manikandan +2 more
doaj +1 more source
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]
Open Biology, 2021 Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
doaj +1 more source
Communications Biology, 2021 Lauren Malave et al. examine the impact of sonic hedgehog signaling in the dorsal striatum in L-Dopa induced dyskinesia (LID) animal models. Their results suggest that increasing sonic hedgehog signaling can reduce the severity of LID and abnormal ...
Lauren Malave +9 more
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Frontiers in Cell and Developmental Biology, 2023 Development of the cerebellum is characterized by rapid proliferation of cerebellar granule cell precursors (GCPs) induced by paracrine stimulation of Sonic hedgehog (Shh) signaling from Purkinje cells, in the external granular layer (EGL). Then, granule
Luana Abballe +14 more
doaj +1 more source
RUNX3 gene expression confers an independent Overall survival advantage in non-M3 adult acute myeloid leukemia patients in Egypt. [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2020 Pretreatment bone marrow samples from 46 newly diagnosed acute myeloid leukemia (AML) patients were analyzed by qRT-PCR. The aim of the present study was to evaluate mRNA expression of RUNX1,2 and 3 along with the hedgehog ligands Indian hedgehog(IHH ...
Nagwa Hassan +4 more
doaj +1 more source
Aging, 2015 The Hedgehog (Hh) signal transduction pathway has been discovered as a central regulator of embryonic development, tissue maintenance and repair [1]. Moreover, several recent evidences have highlighted its key function in tumorigenesis [2]. In some familial cancers, such as basal cell carcinoma and medulloblastoma, Hh pathway activation represents the ...
Laukkanen M, Gutkind J, Castellone M
openaire +5 more sources