Results 41 to 50 of about 37,487 (203)

Anti-apoptotic effect of the Shh signaling pathway in cigarette smoke extract induced MLE 12 apoptosis

Tobacco Induced Diseases, 2019
Introduction Many studies have shown that COPD is associated with apoptosis of bronchial or alveolar epithelial cells. Alveolar type II epithelial cells (AECII) play an important role in the pathogenetic process.
Jinhua Li, Dandan Zong, Yan Chen, Ping Chen   +3 more
doaj   +1 more source

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]

, 2015
Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In, Barbarulo, Alessandro, Crompton, T, Barbarulo, A, Saldana, JI, Sahni, H, D'Acquisto, Fulvio, Solanki, Anisha, Sahni, Hemant, Crompton, Tessa, D'Acquisto, F, Saldana, Jose Ignacio, Solanki, A, Lau, C-I, D’Acquisto, Fulvio, Furmanski, AL, Furmanski, Anna L, Lau, CI, Furmanski, Anna   +18 more
core   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infraorbital blood–nerve barrier following chronic constriction injury?

Molecular Pain, 2017
Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A Romero, Babette B Weksler, Luis Villanueva, Michel Pohl, Yves Boucher   +7 more
doaj   +1 more source

Sonic Hedgehog, Apoptosis, and the Penis [PDF]

The Journal of Sexual Medicine, 2009
ABSTRACT Introduction Smooth muscle apoptosis in the penis is common in prostatectomy patients and animal models of erectile dysfunction (ED). A critical regulator of smooth muscle apoptosis in the penis is the secreted protein Sonic hedgehog (SHH).
openaire   +2 more sources

Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats

Molecular Pain, 2018
Treating bone cancer pain continues to be a clinical challenge and underlying mechanisms of bone cancer pain remain elusive. Here, we reported that sonic hedgehog signaling plays a critical role in the development of bone cancer pain.
Su Liu, You Lv, Xin-Xin Wan, Zhi-Jing Song, Yue-Peng Liu, Shuai Miao, Guang-Lei Wang, Gong-Jian Liu   +7 more
doaj   +1 more source

Targeted therapy done right: Direct sonic hedgehog inhibition for sonic hedgehog medulloblastoma. [PDF]

Neuro Oncol
Nellan A, Jackson S.
europepmc   +3 more sources

Sonic Hedgehog Signaling and Tooth Development [PDF]

International Journal of Molecular Sciences, 2020
Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian embryogenesis. During tooth development, Shh is primarily expressed in the dental epithelium, from initiation to the root formation stages. A number of studies have analyzed the function of Shh signaling at different stages of tooth development and have revealed that Shh ...
Akihiro Hosoya, Nazmus Shalehin, Hiroaki Takebe, Tsuyoshi Shimo, Kazuharu Irie   +4 more
openaire   +2 more sources

Penile remodeling, Sonic hedgehog, and fibrosis. [PDF]

J Sex Med
Podlasek CA.
europepmc   +3 more sources

7-Ketocholesterol and cholestane-triol increase expression of SMO and LXRα signaling pathways in a human breast cancer cell line

Biochemistry and Biophysics Reports, 2019
Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of 7-ketocholesterol (7-KC), cholestane-3β-5α-6β-triol (triol), and
Debora Levy, Thatiana Correa de Melo, Beatriz A. Oliveira, Jessica L. Paz, Fabio A. de Freitas, Cadiele O. Reichert, Alessandro Rodrigues, Sergio P. Bydlowski   +7 more
doaj   +1 more source

Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation. [PDF]

PLoS ONE, 2015
Dicer, a ribonuclease III enzyme, is required for the maturation of microRNAs. To assess its role in cerebellar and medulloblastoma development, we genetically deleted Dicer in Nestin-positive neural progenitors and in mice lacking one copy for the Sonic
Frederique Zindy, Youngsoo Lee, Daisuke Kawauchi, Olivier Ayrault, Leila Ben Merzoug, Yang Li, Peter J McKinnon, Martine F Roussel   +7 more
doaj   +1 more source