Results 41 to 50 of about 61,899 (269)

Sonic Hedgehog Signaling in Limb Development [PDF]

Frontiers in Cell and Developmental Biology, 2017
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies ...
Tickle, C., Towers, M.
openaire   +4 more sources

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]

, 2016
Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C, CARDINALI, CLAUDIO, GISMONDI, Angela, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, G., Santoni, M   +6 more
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7-Ketocholesterol and cholestane-triol increase expression of SMO and LXRα signaling pathways in a human breast cancer cell line

Biochemistry and Biophysics Reports, 2019
Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of 7-ketocholesterol (7-KC), cholestane-3β-5α-6β-triol (triol), and
Debora Levy, Thatiana Correa de Melo, Beatriz A. Oliveira, Jessica L. Paz, Fabio A. de Freitas, Cadiele O. Reichert, Alessandro Rodrigues, Sergio P. Bydlowski   +7 more
doaj   +1 more source

Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing

Cell Regeneration, 2023
The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng, Ximei Wu   +7 more
doaj   +1 more source

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning [PDF]

, 2007
Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network.
Davidson, Eric H., Giles, Shane, Ji, Hongkai, Longabaugh, William J. R., McCuine, Scott, McMahon, Andrew P., Tenzen, Toyoaki, Vokes, Steven A., Wong, Wing H., Zhong, Sheng   +9 more
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Sonic Hedgehog Signaling and Tooth Development [PDF]

International Journal of Molecular Sciences, 2020
Sonic hedgehog (Shh) is a secreted protein with important roles in mammalian embryogenesis. During tooth development, Shh is primarily expressed in the dental epithelium, from initiation to the root formation stages. A number of studies have analyzed the function of Shh signaling at different stages of tooth development and have revealed that Shh ...
Akihiro Hosoya, Nazmus Shalehin, Hiroaki Takebe, Tsuyoshi Shimo, Kazuharu Irie   +4 more
openaire   +2 more sources

Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights

Neural Regeneration Research
Over the past few decades, the Sonic Hedgehog protein has become a pivotal player in many biological processes, including tumourigenesis, embryonic development, and protective mechanisms after cerebral damage.
Nuokun Li, Shiyi Wen, Dandan Li, Yaning Shi, Zhigang Mei, Danhong Liu, Hui Yang, Yuhong Wang, Xiaoyuan Lin, Yun Xiang, Hongbo Wen, Pan Meng   +11 more
doaj   +1 more source

Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.

PLoS ONE, 2013
In this study, we examined the expression of Sonic Hedgehog, Patched, Gli1, Gli2, Gli3 and Myocardin in the developing bladders of male and female normal and megabladder (mgb-/-) mutant mice at embryonic days 12 through 16 by in situ hybridization.
Kristin R DeSouza, Monalee Saha, Ashley R Carpenter, Melissa Scott, Kirk M McHugh   +4 more
doaj   +1 more source

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. [PDF]

, 2018
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown,
A Dagklis, A Dagklis, A El Andaloussi, A Gutierrez, A Sekulic, AA Ferrando, AE Place, AK Fielding, AL Furmanski, AM Kenney, C Reynolds, CH Pui, CJ Neumann, DD Hoff Von, DI Marks, DM Stone, DV Catenacci, E Drakopoulou, E Lindstrom, GW Robinson, H Hahn, H Hahn, HA Zahreddine, HJ Sharpe, I Hofmann, J Briscoe, J Chen, J Gao, J Rodon, J Taipale, JM Goldberg, JS Blackburn, JY Tang, KD Robarge, LV Goodrich, M Aszterbaum, M Duman-Scheel, M Sadelain, M Schrappe, MJ Koudijs, NJ Rowbotham, PD Bhola, PD Stenson, PL So, PM LoRusso, RH Ko, RL Johnson, S Hettmer, SB Kaye, SP Hunger, SS Winter, SV Outram, T Ni Chonghaile, TT Vo, Y Liu   +54 more
core   +1 more source

Sonic hedgehog pathway expression in non-small cell lung cancer

Therapeutic Advances in Medical Oncology, 2012
Objective: Activation of the hedgehog pathway is an important signaling mechanism crucial in embryogenesis and has strong links to carcinogenesis. This study investigates the expression of the Sonic hedgehog pathway molecules in non-small cell lung ...
Malvi Savani, Yan Guo, David P. Carbone, Ildiko Csiki   +3 more
doaj   +1 more source