Results 61 to 70 of about 37,487 (203)

Coordination of limb bud development : the role of SHH in PD limb bud patterning [PDF]

, 2012
The limb bud serves as an excellent model to investigate the signals involved in diverse processes during embryonic development. Limb bud development is controlled by complex regulatory networks that instruct coordinated patterning and proliferation of ...
Probst, Simone
core   +1 more source

Regulation of Thalamic Development by Sonic Hedgehog [PDF]

Frontiers in Neuroscience, 2012
The thalamus is strategically positioned within the caudal diencephalic area of the forebrain, between the mesencephalon and telencephalon. This location is important for unique aspects of thalamic function, to process and relay sensory and motor information to and from the cerebral cortex.
openaire   +3 more sources

Sonic hedgehog and CDX2 expression in the stomach [PDF]

Journal of Gastroenterology and Hepatology, 2008
AbstractSonic hedgehog (Shh) is an essential regulator of patterning processes throughout development, and CDX proteins act as the master regulators for intestinal development and differentiation. Shh and CDX2 seem to be interdependently linked with cellular differentiation through different signal cascades.
Akiko, Shiotani, Tomoari, Kamada, Yoshiyuki, Yamanaka, Noriaki, Manabe, Hiroaki, Kusunoki, Jiro, Hata, Ken, Haruma   +6 more
openaire   +2 more sources

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei

, 2011
Background: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN).
Joyner, Alexandra L., Stephen Daniel, Chanet, S., Chanet, Soline, Blaess, S., Emilie Mugniery, Sandra Blaess, Joyner, L., Daniel Stephen, Soline Chanet, Mugniery, E., Kabanova, Anna, Bodea, G., Blaess, Sandra, Derouiche, Amin, Alexandra L Joyner, Mugniery Emilie, Gabriela O Bodea, Chanet Soline, Joyner, Alexandra, Joyner Alexandra L, Bodea, Gabriela O., Mugniery, Emilie, Derouiche, A., Blaess Sandra, Stephen, D., Kabanova, A., Derouiche Amin, Bodea Gabriela O, Bodea, Gabriela, Kabanova Anna, Anna Kabanova, Stephen, Daniel, Amin Derouiche   +33 more
core   +1 more source

HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization

Cell Death and Disease
Sonic Hedgehog signaling is aberrantly activated in non-small cell lung cancer (NSCLC). However, the regulatory molecules of Sonic Hedgehog signaling during NSCLC development are still largely unknown. Here, we demonstrated that HHIP Like 2 (HHIPL2) is a
Ning Mu, Fanrong Liu, Xiangqing Song, Biao Wang, Yilin Zhu, Lingbing Li, Lingxiao Yang, Huacong Sui, Jinfu Wang, Fengyuan Gao, Yongjia Zhou, Yanfeng Lv, Zhongxian Tian, Peichao Li, Xiaogang Zhao   +14 more
doaj   +1 more source

Novel variant in HHAT as a cause of different sex development with partial gonadal dysgenesis associated with microcephaly, eye defects, and distal phalangeal hypoplasia of both thumbs: Case report

Frontiers in Endocrinology, 2022
The palmitoylation of the Hedgehog (Hh) family of morphogens, named sonic hedgehog (SHH), desert hedgehog (DHH), and Indian hedgehog (IHH), is crucial for effective short- and long-range signaling.
Noelia Baz-Redón, Noelia Baz-Redón, Laura Soler-Colomer, Mónica Fernández-Cancio, Mónica Fernández-Cancio, Sara Benito-Sanz, Sara Benito-Sanz, Marta Garrido, Teresa Moliné, María Clemente, María Clemente, María Clemente, María Clemente, Núria Camats-Tarruella, Núria Camats-Tarruella, Diego Yeste, Diego Yeste, Diego Yeste, Diego Yeste   +18 more
doaj   +1 more source

La vía Sonic Hedgehog en el sistema nervioso: del embrión al tumor

Acta Neurológica Colombiana
Introducción: la vía Sonic Hedgehog regula procesos clave en el desarrollo del sistema nervioso central, como la especificación neuronal, la migración celular y la proliferación de células precursoras en el cerebelo.
Nicolás Yory Montalvo, Feilpe Velásquez García, Lina V. Becerra-Hernández   +2 more
doaj   +1 more source

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

Nature Communications, 2019
Hedgehog (Hh) controls embryonic development via interaction with its receptor Patched (Ptch). Here the authors report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhNp)
Hongwu Qian, Pingping Cao, Miaohui Hu, Shuai Gao, Nieng Yan, Xin Gong   +5 more
doaj   +1 more source

Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane

Cell Reports, 2019
Summary: Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the endoplasmic reticulum (ER) by Hedgehog acyltransferase (Hhat), an ER-resident enzyme ...
James J. Asciolla, Marilyn D. Resh
doaj   +1 more source

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

Cell Death and Disease, 2021
Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells.
Nunzio Vicario, Federica M. Spitale, Daniele Tibullo, Cesarina Giallongo, Angela M. Amorini, Grazia Scandura, Graziana Spoto, Miriam W. Saab, Simona D’Aprile, Cristiana Alberghina, Renata Mangione, Joshua D. Bernstock, Cirino Botta, Massimo Gulisano, Emanuele Buratti, Giampiero Leanza, Robert Zorec, Michele Vecchio, Michelino Di Rosa, Giovanni Li Volti, Giuseppe Lazzarino, Rosalba Parenti, Rosario Gulino   +22 more
doaj   +1 more source