Results 81 to 90 of about 116,918 (241)

Shh–S100A10 axis curbs neuronal PANoptosis after ischemic stroke

Neural Regeneration Research
Acute ischemic stroke is a highly prevalent and disabling disease with poor prognosis. Neuronal death is a major feature after a stroke. PANoptosis is a newly reported pattern of cell death, characterized by pyroptosis, apoptosis, and necroptosis, that ...
Ling Wang, Hao Tang, Jun Wen, Qinghuan Yang, Jiagui Huang, Yong Zhao, Yu Ren, Qin Yang   +7 more
doaj   +1 more source

Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]

, 2012
Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
core   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling

Nature Communications, 2022
The small intestine forms via crosstalk between epithelial and mesenchymal cell compartments. Here, the authors show that a gradient of Wnt signalling along the anterior-posterior axis regulates Sonic Hedgehog which is required for correct formation and ...
Martti Maimets, Marianne Terndrup Pedersen, Jordi Guiu, Jes Dreier, Malte Thodberg, Yasuko Antoku, Pawel J. Schweiger, Leonor Rib, Raul Bardini Bressan, Yi Miao, K. Christopher Garcia, Albin Sandelin, Palle Serup, Kim B. Jensen   +13 more
doaj   +1 more source

Sonic Hedgehog Signaling and Development of the Dentition [PDF]

Journal of Developmental Biology, 2017
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the ...
Seppala, M., Fraser, G., Birjandi, A., Xavier, G., Cobourne, M.   +4 more
openaire   +6 more sources

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Sonic Hedgehog signaling in the mammalian brain [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 113, 576–590.AbstractThe discovery of a Sonic Hedgehog (Shh) signaling pathway in the mature vertebrate CNS has paved the way to the characterization of the functional roles of Shh signals in normal and diseased brain. Shh is proposed to participate in the establishment and maintenance of adult neurogenic niches and to regulate ...
Traiffort, Elisabeth, Angot, Elodie, Ruat, Martial   +2 more
openaire   +2 more sources

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts [PDF]

, 2009
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
core  

Coordination of limb bud development : the role of SHH in PD limb bud patterning [PDF]

, 2012
The limb bud serves as an excellent model to investigate the signals involved in diverse processes during embryonic development. Limb bud development is controlled by complex regulatory networks that instruct coordinated patterning and proliferation of ...
Probst, Simone
core   +1 more source