Results 81 to 90 of about 61,899 (269)
Systemic Sonic Hedgehog Signaling Links Intestinal Nutrient Sensing With Sex-Specific Type 2 Diabetes Progression. [PDF]
FASEB JHere, Systemic Sonic Hedgehog (Shh) emerges as a sex‐specific metabolic signal and potential biomarker. Across two large cohorts, Shh rose selectively in females with type 2 diabetes, with a sharp pre‐diagnostic increase in about one‐quarter of cases, indicating value for early risk stratification.
Alfredsson J +11 more
europepmc +2 more sources
Targeting GLI factors to inhibit the Hedgehog pathway [PDF]
, 2015 Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina +4 more
core +2 more sources
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Molecular classification of hepatocellular adenomas: impact on clinical practice
Hepatic Oncology, 2018 Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10–20%) and malignant transformation into hepatocellular carcinoma (
Anne-Laure Védie +3 more
doaj +1 more source
The transcriptional landscape of Shh medulloblastoma
Nature Communications, 2021 Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular ...
Patryk Skowron +98 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation ...
Dominique Manikowski +6 more
doaj +1 more source
Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite [PDF]
, 1997 Shortly after their formation, somites of vertebrate embryos differentiate along the dorsoventral axis into sclerotome, myotome and dermomyotome.
Bronner-Fraser, Marianne +2 more
core
Microparticles harboring sonic hedgehog [PDF]
Cell Adhesion & Migration, 2009 Sonic Hedgehog (Shh) is a morphogen involved in embryonic development of nervous system. Also, it has been shown that recombinant Shh can modulate angiogenesis under ischemic conditions. However, angiogenic effects of endogenous Shh have not been completely elucidated. Using small membrane-derived vesicles expressing Shh (MPs(Shh+)), we have shown that,
Soleti, Raffaella +1 more
openaire +3 more sources
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling
Nature Communications, 2022 The small intestine forms via crosstalk between epithelial and mesenchymal cell compartments. Here, the authors show that a gradient of Wnt signalling along the anterior-posterior axis regulates Sonic Hedgehog which is required for correct formation and ...
Martti Maimets +13 more
doaj +1 more source