Results 81 to 90 of about 37,487 (203)

Sonic Hedgehog Signaling and Development of the Dentition [PDF]

Journal of Developmental Biology, 2017
Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the ...
Seppala, M., Fraser, G., Birjandi, A., Xavier, G., Cobourne, M.   +4 more
openaire   +6 more sources

Sonic hedgehog as a chemoattractant for adult NPCs [PDF]

Cell Adhesion & Migration, 2010
The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migratory stream (RMS) to the olfactory
Catherine Hong Huan, Hor, Bor Luen, Tang
openaire   +2 more sources

Shh–S100A10 axis curbs neuronal PANoptosis after ischemic stroke

Neural Regeneration Research
Acute ischemic stroke is a highly prevalent and disabling disease with poor prognosis. Neuronal death is a major feature after a stroke. PANoptosis is a newly reported pattern of cell death, characterized by pyroptosis, apoptosis, and necroptosis, that ...
Ling Wang, Hao Tang, Jun Wen, Qinghuan Yang, Jiagui Huang, Yong Zhao, Yu Ren, Qin Yang   +7 more
doaj   +1 more source

Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. [PDF]

PLoS ONE, 2013
The Hedgehog pathway is activated in various types of malignancies. We previously reported that inhibition of SMO or GLI prevents osteosarcoma growth in vitro and in vivo.
Shunsuke Nakamura, Satoshi Nagano, Hiroko Nagao, Yasuhiro Ishidou, Masahiro Yokouchi, Masahiko Abematsu, Takuya Yamamoto, Setsuro Komiya, Takao Setoguchi   +8 more
doaj   +1 more source

Sonic hedgehog expression in the postnatal brain [PDF]

Biology Open, 2019
Beyond its role in patterning the neural tube during embryogenesis, additional functions of Sonic hedgehog (Shh) in post-embryonic and mature brains have been coming into focus. However, the question of the abundance of endogenous Shh – the ligand of the signaling pathway – and its changes over time in post-embryonic and mature brains are less well ...
Aileen Rivell, Ronald S. Petralia, Ya-Xian Wang, Ellie Clawson, Keelin Moehl, Mark P. Mattson, Pamela J. Yao   +6 more
openaire   +3 more sources

NON-OBSERVANCE MAXIMS IN "SONIC THE HEDGEHOG" MOVIE

, 2021
This descriptive qualitative study examined the non-observance maxim in the movie “Sonic the Hedgehog”. It used Grice’s and Cutting’s theories. The non-observance maxim is an interesting topic to analyze because this theory contradicts the theory of ...
Ambalegin, S.Pd., M.Pd., Munthe, Desi
core   +1 more source

Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling

Nature Communications, 2022
The small intestine forms via crosstalk between epithelial and mesenchymal cell compartments. Here, the authors show that a gradient of Wnt signalling along the anterior-posterior axis regulates Sonic Hedgehog which is required for correct formation and ...
Martti Maimets, Marianne Terndrup Pedersen, Jordi Guiu, Jes Dreier, Malte Thodberg, Yasuko Antoku, Pawel J. Schweiger, Leonor Rib, Raul Bardini Bressan, Yi Miao, K. Christopher Garcia, Albin Sandelin, Palle Serup, Kim B. Jensen   +13 more
doaj   +1 more source

GLI1 confers profound phenotypic changes upon LNCaP prostrate cancer cells that include the acquisition of a hormone independent state [PDF]

, 2011
The GLI (GLI1/GLI2) transcription factors have been implicated in the development and progression of prostate cancer although our understanding of how they actually contribute to the biology of these common tumours is limited.
Nadendla Sandeep K., Thomas, GJ, Ward, M, Lucia S. Bianchi, Hazan Allon, Ghali, Lucy, Matt Ward, Ghali Lucy, Lucia S Bianchi, Thomas, Gareth J., Michael P Philpott, Ghali, L, Philpott Michael P., Sandeep K. Nadendla, Ward Matt, Moutasim, K, Neill, GW, David M Prowse, Thomas Gareth J., Prowse, DM, Sandeep K Nadendla, Philpott, MP, Bianchi, Lucia S., Mahmoud Naase, Harper, LJ, Naase Mahmoud, Hazan, Allon, Moutasim Karwan, Philpott, Michael P., Moutasim, Karwan, Lisa J Harper, Nadendla, Sandeep K., Prowse David M., Gareth J. Thomas, Harper Lisa J., Ward, Matt, Lucy Ghali, Nadendla, SK, Allon Hazan, Hazan, A, Bianchi Lucia S., Gareth J Thomas, Graham W Neill, Karwan Moutasim, David M. Prowse, Naase, Mahmoud, Bianchi, LS, Lisa J. Harper, Prowse, David M., Harper, Lisa J., Graham W. Neill, Naase, M, Neill Graham W., Michael P. Philpott, Neill, Graham W.   +54 more
core   +1 more source

Relationship between DNA methylation mechanism and Sonic Hedgehog family (SSH) genes in carcinogenesis and tumorigenesis of gastrointestinal cancers

Journal of Current Oncology and Medical Sciences, 2022
Gastrointestinal cancers are among the most serious cancers. In addition to environmental factors, genetic and epigenetic factors also play a key role in the development of gastrointestinal cancers.
Sogand Vahidi , Fatemeh Nejatifar , Seyedeh Elham Norollahi , Ali Akbar Samadani   +3 more
doaj  

Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems

, 2007
PhDEmbryonic development is regulated by a number of signalling pathways, Which are critical for normal growth. Many of these genes then continue to play an important role in the regulation of cell growth and differentiation in adult.
Ikram, Mohammed S, Ikram, Mohammed. S.
core