Results 91 to 100 of about 37,487 (203)

Differential regulation of tyrosine hydroxylase expression by sonic hedgehog.

, 2006
Sonic hedgehog functions to induce floor plate in early stages, and spinal motor neurons and midbrain dopaminergic neurons in later stages of development.
Kim, SU, Young Don Lee, Suh-Kim, H, Kwon, IS, II Sun Kwon, Seung U. Kim, Haeyoung Suh-Kim, Choi, JM, Jung Mi Choi, Lee, YD, Rae Hee Park, Park, RH   +11 more
core   +1 more source

Genomic factors that shape craniofacial outcome and neural crest vulnerability in FASD

Frontiers in Genetics, 2014
Prenatal alcohol exposure (PAE) causes distinctive facial characteristics in some pregnancies and not others; genetic factors may contribute to this differential vulnerability.
Susan M. Smith, Ana eGaric, Mark E. Berres, George R. Flentke   +3 more
doaj   +1 more source

The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts

, 2009
The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry Gipp, Wade Bushman
core  

Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development

, 1996
Sonic hedgehog is a secreted factor regulating patterning of the anterior–posterior axis in the developing limb. The signaling pathway mediating the transduction of the signal is still poorly understood.
Johnson, Randy L., Tabin, Clifford J., Vortkamp, Andrea, Marigo, Valeria   +3 more
core   +2 more sources

Sonic Hedgehog Signaling Switches the Mode of Division in the Developing Nervous System

Cell Reports, 2013
The different modes of stem cell division are tightly regulated to balance growth and differentiation during organ development and homeostasis, and these regulatory processes are subverted in tumor formation.
Murielle Saade, Irene Gutiérrez-Vallejo, Gwenvael Le Dréau, M. Angeles Rabadán, David G. Miguez, Javier Buceta, Elisa Martí   +6 more
doaj   +1 more source

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

Is sonic hedgehog expression in saliva related to taste sensitivity in adults?

, 2021
Recent studies have demonstrated the critical role of the sonic hedgehog in the sensory perception of taste. Salivary sonic hedgehog stimulates taste bud stem cells, also acts as a taste bud growth factor, and contributes to the receptors' development ...
DİKMEN, DERYA, ÖZTÜRK, ELİF ESRA
core   +1 more source

Mapping the Shh long-range regulatory domain

, 2014
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Hill, Robert E, Devenney, Paul S, Lettice, Laura A, Anderson, Eve   +3 more
core   +1 more source

Regulation of Patched by Sonic hedgehog in the developing neural tube.

, 1996
Ventral cell fates in the central nervous system are induced by Sonic hedgehog, a homolog of hedgehog, a secreted Drosophila protein. In the central nervous system, Sonic hedgehog has been identified as the signal inducing floor plate, motor neurons, and
MARIGO, Valeria, Tabin, Clifford
core   +1 more source

Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats

Cellular Physiology and Biochemistry, 2016
Background/Aims: Lipid accumulation, inflammatory responses and oxidative stress have been implicated in the pathology of alcoholic liver disease (ALD). Targeting inhibition of these features may provide a promising therapeutic strategy for ALD. Baicalin,
Huifen Wang, Yanli Zhang, Ruxue Bai, Miao Wang, Shiyu Du   +4 more
doaj   +1 more source