Results 111 to 120 of about 116,918 (241)
Mapping of the cell population expressing Sonic hedgehog during the embryonic development of heart [PDF]
, 2022 Sonic hedgehog is one of three members of the Hedgehog family, whose signaling pathway plays a crucial role in controlling the development of vertebrates. Sonic hedgehog has an important role in organizing the developmental processes of majority of organ
Břežná, Veronika
core
Fast-tracking morphogen diffusion [PDF]
, 2006 The readout of morphogen concentrations has been proposed to be an essential mechanism allowing embryos to specify cell identities (Wolpert Trends Genet 12 (1996) 359), but theoretical and experimental results have led to conflicting ideas as to how ...
Olivier Cinquin, Cinquin, O
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Pediatric Dermatology, EarlyView.ABSTRACT Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare skin disorder characterized by pruritic, erythematous, and scaly plaques following Blaschko's lines. Known genetic causes include somatic variants in CARD14 and GJA1. In addition, a similar phenotype of congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD ...
Janan Mohamad +10 more
wiley +1 more source
Understanding Exosomes in Hair Regeneration
Periodontology 2000, EarlyView.Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad +3 more
wiley +1 more source
Differential regulation of tyrosine hydroxylase expression by sonic hedgehog.
, 2006 Sonic hedgehog functions to induce floor plate in early stages, and spinal motor neurons and midbrain dopaminergic neurons in later stages of development.
Kim, SU +11 more
core +1 more source
A 30‐year‐old woman with progressive lower extremity sensory loss and weakness
Brain Pathology, EarlyView.
Daniel W. Griepp +4 more
wiley +1 more source
Loss, persistence and reversal of phenotypic traits
Biological Reviews, Volume 101, Issue 5, Page 2119-2133, October 2026.ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
wiley +1 more source
Medulloblastoma tumor suppressor factor RENKCTD11: structure and function based design and development of new compounds of theraupetical interest. [PDF]
, 2009 Hedgehog (Hh) signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors.
Pirone, Luciano
core +1 more source
International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini +6 more
wiley +1 more source
ProceedingsAims: Medulloblastoma (MBs), the most prevalent malignant paediatric brain tumour, exhibits distinct subgroups—Wingless (WNT), Sonic Hedgehog (SHH), Group 3 (G3), and Group 4 (G4)—and each is characterized by unique molecular signatures and clinical ...
Charley Comer +1 more
doaj +1 more source