Results 111 to 120 of about 37,487 (203)

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

, 2003
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role in ...
Calcutt, Nigel A., Allendoerfer, Karen L., Alphonse Galdes, Jean-Dominique Delcroix, Burgers, Monica, Jason D. Freshwater, Ranciato, Rigel, Delcroix, Jean Dominique, Nigel A. Calcutt, Andrew P. Mizisin, Monica Burgers, Dudek, Henryk, Engber, Thomas M., Frederick R. Taylor, Middlemas, Alicia, Renee Shapiro, Thomas M. Engber, Kathy Strauch, Rubin, Lee L., Tomlinson, David R., Freshwater, Jason D., Karen L. Allendoerfer, Mizisin, Andrew P., Alicia Middlemas, Taylor, Frederick R., Lee L. Rubin, David R. Tomlinson, Shapiro, Renee, Strauch, Kathy, Galdes, Alphonse, Rigel Ranciato, Henryk Dudek   +31 more
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Medulloblastoma tumor suppressor factor RENKCTD11: structure and function based design and development of new compounds of theraupetical interest.

, 2009
Hedgehog (Hh) signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors.
Pirone, Luciano
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The NH2-terminal region of the active domain of sonic hedgehog is necessary for its signal transduction

, 1999
The NH2-terminal domain of sonic hedgehog (residue 25–198) was expressed in both yeast and animal cells. The yeast-derived NH2-terminal domain of sonic hedgehog was less active by far than the animal cell-derived counterpart.
Michio Kimura, Wagatsuma, Masako, Kimura, Michio, Sachiko Yanagisawa, Yanagisawa, Sachiko, Masako Wagatsuma, Hosono-Sakuma, Yoshiko, Okazaki, Makoto, Yoshiko Hosono-Sakuma, Makoto Okazaki, Katsuura, Mieko, Mieko Katsuura   +11 more
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A5_1 Super Sonic (the Hedgehog)

, 2017
In the popular game franchise Sonic The Hedgehog Sonic has several powers. For example he can move at the speed of sound, and is able to transform into Super Sonic- a gold version of himself who can move close to the speed of light[1].
Pitts, Michael J, Howe, Rebecca, Scanlan, Fraser R.J, Javaid, Rafia   +3 more
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HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma

, 2018
Medulloblastoma is the most common paediatric malignant brain cancer and there is a need for new targeted therapeutic approaches to more effectively treat these malignant tumours, which can be divided into four molecular subtypes.
Jonathan B. Bell, C. Shad Thaxton, Jonathan S. Rink, Jessica Clymer, Leonidas C. Platanias, Frank Eckerdt, Stewart Goldman   +6 more
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Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb.

, 1996
Hedgehog genes have been implicated in inductive signaling during development in a variety of organisms. A key element of the hedgehog signaling system is encoded by the gene patched.
MARIGO, Valeria, TABIN C. J., GOODRICH L. V., SCOTT M. P., JOHNSON R. L.   +4 more
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Downstream effects of Sonic hedgehog on glis3 and insulin expression

, 2022
Sonic hedgehog is known to play both permissive and restrictive roles during the formation of the pancreas in zebrafish. Glis3 is a transcription factor that has been implicated in the specification of insulin producing cells within the pancreas during ...
Shroat, Delaney
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Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression

, 2018
Su Liu,1,2,* Jun-Li Yao,1,3,* Xin-Xin Wan,1,* Zhi-Jing Song,1 Shuai Miao,1,2 Ye Zhao,1,2 Xiu-Li Wang,1,2 Yue-Peng Liu4 1Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu, China; 2Department of Anesthesiology ...
Liu Y, Yao J, Miao S, Liu S, Wan X, Wang X, Song Z, Zhao Y   +7 more
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Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells

, 2002
Sonic Hedgehog is a secreted morphogen involved in patterning a wide range of structures in the developing embryo. Disruption of the Hedgehog signalling cascade leads to a number of developmental disorders and plays a key role in the formation of a range
Forrest, A. R., Forrest, Alistair, Grimmond, S. M., Wainwright, B. J., Grimmond, Sean, Wainwright, Brandon J., Wicking, Carol, Ingram, W. J., J Ingram, Wendy, Wicking, C. A.   +9 more
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The role of GLI2 in human basal cell carcinoma tumourigenesis

, 2010
PhDAbnormal Sonic Hedgehog (SHH) signalling leads to increased transcriptional activation of its downstream effector, GLI2, which is implicated in the pathogenesis of a variety of human tumours, including human basal cell carcinoma (BCC).
Pantazi, Eleni
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