Results 71 to 80 of about 37,487 (203)

C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation

Frontiers in Cell and Developmental Biology, 2021
Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation ...
Dominique Manikowski, Philipp Kastl, Sabine Schürmann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe   +6 more
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Mapping of the cell population expressing Sonic hedgehog during the embryonic development of heart [PDF]

, 2022
Sonic hedgehog is one of three members of the Hedgehog family, whose signaling pathway plays a crucial role in controlling the development of vertebrates. Sonic hedgehog has an important role in organizing the developmental processes of majority of organ
Břežná, Veronika
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Activation of the hedgehog pathway in advanced prostate cancer

Molecular Cancer, 2004
Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore,
McCormick Frank, Chen Kai, He Nonggao, Chi Sumin, Zhang Xiaoli, Li Chengxin, Sheng Tao, Gatalica Zoran, Xie Jingwu   +8 more
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Epithelial Trafficking of Sonic Hedgehog by Megalin [PDF]

Journal of Histochemistry & Cytochemistry, 2006
We present here evidence of in vivo epithelial endocytosis and trafficking of non-lipid-modified Sonic hedgehog (ShhN) when infused into rat efferent ducts via microinjection. Initially, exogenous ShhN is detected in endocytic vesicles and early endosomes located near the apical plasma membrane of non-ciliated cells. Within 30-60 min following infusion,
Carlos R, Morales, Jibin, Zeng, Mohamed, El Alfy, Jeremy L, Barth, Mastan Rao, Chintalapudi, Robert A, McCarthy, John P, Incardona, W Scott, Argraves   +7 more
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Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function

Biology Open, 2014
Holoprosencephaly is a heterogeneous developmental malformation of the central nervous system characterized by impaired forebrain cleavage, midline facial anomalies and wide phenotypic variation.
Maisa Seppala, Guilherme M. Xavier, Chen-Ming Fan, Martyn T. Cobourne   +3 more
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Sonic Hedgehog signaling in the mammalian brain [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 113, 576–590.AbstractThe discovery of a Sonic Hedgehog (Shh) signaling pathway in the mature vertebrate CNS has paved the way to the characterization of the functional roles of Shh signals in normal and diseased brain. Shh is proposed to participate in the establishment and maintenance of adult neurogenic niches and to regulate ...
Traiffort, Elisabeth, Angot, Elodie, Ruat, Martial   +2 more
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Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones [PDF]

, 2005
In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol ...
Schilling, TF, Geisler, Robert, Norton, W H, Houart, Corinne, Diamond, B, Mangoli, Maryam, Brianne Diamond, Rees, M., Stephen W. Wilson, Strähle, U., Talbot, W., Norton, W., Diamond, B., Schilling, T., William S. Talbot, Gerd-Jörg Rauch, Frohnhoefer, Hans-Georg, Talbot, WS, Max Planck, Forschungszentrum Karlsruhe, Carl-Philipp Heisenberg, Mercurio, S., Heisenberg, C., Diamond, Brianne, Claire Russell, Pogoda, H., Geisler, R. ; https://orcid.org/, Sara Mercurio, Stickney, Heather L, Neumann, CJ, Heisenberg, C P, Mercurio, Sara, Maryam Mangoli, Gardiner, R M, Stickney, HL, Neumann, C J, Zsolt Lele, Frohnhoefer, HG, Norton, Will H, Sepand Rastegar, Russell, C., Pogoda, HM, Stanford University, Wilson, Stephen W, Will H. Norton, Hans-Georg Frohnhoefer, Neumann, Carl J, Neumann, C., Norton, WH, Rauch, Gerd-Jörg, Geisler, R, Heisenberg, Carl-Philipp, Heather L. Stickney, Schilling, T F, Stickney, H., UCL, Lele, Z, Mangoli, M., Uwe Strähle, Wilson, SW, Russell, C, Rauch, G., Pogoda, H M, R. Mark Gardiner, Gardiner, R., Carl J. Neumann, Houart , C., Rastegar, S., Pogoda, Hans-Martin, Thomas F. Schilling, Rees, M, Houart, C, Mangoli, M, Teraoka, Hiroki, Gardiner, RM, Rastegar, Sepand, Wilson, S., Teraoka, H, Strahle, U, Heidelberg, Frohnhoefer, H G, Rastegar, S, Gardiner, R Mark, Hiroki Teraoka, Lele, Z., Russell, Claire, Rees, Michelle, Robert Geisler, Lele, Zsolt, Heisenberg, CP, Stickney, H L, Hans-Martin Pogoda, Corinne Houart, Talbot, W S, Wilson, S W, Inserm, Paris, Rauch, G J, Schilling, Thomas F, Frohnhöfer, H. ; https://orcid.org/, Michelle Rees, Strähle, Uwe, Rauch, GJ, Teraoka, H., Mercurio, S, Talbot, William S   +104 more
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Molecular classification of hepatocellular adenomas: impact on clinical practice

Hepatic Oncology, 2018
Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10–20%) and malignant transformation into hepatocellular carcinoma (
Anne-Laure Védie, Olivier Sutter, Marianne Ziol, Jean-Charles Nault   +3 more
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The transcriptional landscape of Shh medulloblastoma

Nature Communications, 2021
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular ...
Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor   +98 more
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Sonic Hedgehog Signaling in Limb Development [PDF]

Frontiers in Cell and Developmental Biology, 2017
The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the posterior margin of the vertebrate limb bud. Detailed analyses have revealed that Shh has the properties of the long sought after polarizing region morphogen that specifies ...
Tickle, C., Towers, M.
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