Results 51 to 60 of about 37,487 (203)
Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.
PLoS ONE, 2013 In this study, we examined the expression of Sonic Hedgehog, Patched, Gli1, Gli2, Gli3 and Myocardin in the developing bladders of male and female normal and megabladder (mgb-/-) mutant mice at embryonic days 12 through 16 by in situ hybridization.
Kristin R DeSouza +4 more
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, 2013 The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk +5 more
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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Frontiers in Cellular and Infection Microbiology, 2022 ObjectivesTo investigate the pathogenic effect of Porphyromonas gingivalis cultured media on the esophagus and the mechanism underlying the effect.BackgroundPeriodontitis is strongly associated with esophageal squamous cell carcinoma (ESCC). The cultured
Xueting Jia +7 more
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Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]
, 2012 Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
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Sonic Hedgehog Signaling and Hippocampal Neuroplasticity [PDF]
Trends in Neurosciences, 2016 Sonic hedgehog (Shh) is a secreted protein that controls the patterning of neural progenitor cells, and their neuronal and glial progeny, during development. Emerging findings suggest that Shh also has important roles in the formation and plasticity of neuronal circuits in the hippocampus, a brain region of fundamental importance in learning and memory.
Pamela J, Yao +2 more
openaire +2 more sources
Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
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Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin. [PDF]
PLoS ONE, 2012 Oligodendrocyte differentiation is temporally regulated during development by multiple factors. Here, we investigated whether the timing of oligodendrocyte differentiation might be controlled by neuronal differentiation in cerebellar organotypic cultures.
Lamia Bouslama-Oueghlani +8 more
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Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation
, 2009 We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V +17 more
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The role of Sulf1 during Sonic hedgehog mediated neural patterning [PDF]
, 2011 Heparan sulphate proteoglycans (HSPGs) are large molecules distributed ubiquitously, both at the cell surface and within the extracellular matrix. These molecules are known to play essential roles in developmental cell signalling, and the differential ...
Ramsbottom, Simon A, Ramsbottom, Simon.A
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