Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]
, 2012 Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
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Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. [PDF]
PLoS ONE, 2010 BACKGROUND: Microparticles (MPs) are vesicles released from plasma membrane upon cell activation and during apoptosis. Human T lymphocytes undergoing activation and apoptosis generate MPs bearing morphogen Shh (MPs(Shh+)) that are able to regulate in ...
Tarek Benameur +4 more
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Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. [PDF]
PLoS ONE, 2010 BackgroundWe hypothesized that genetic modification of mesenchymal stem cells (MSCs) with Sonic Hedgehog (Shh) transgene, a morphogen during embryonic development and embryonic and adult stem cell growth, improved their survival and angiogenic potential ...
Rafeeq P H Ahmed +4 more
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PSEN1 Expression Identifies a Developmentally Distinct Favourable-Prognosis State in SHH α Medulloblastoma. [PDF]
Int J Dev NeurosciHigh PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Vanini J +6 more
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Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH. [PDF]
PLoS ONE, 2014 INTRODUCTION: Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis.
Stefan Eipeldauer +7 more
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Sonic Hedgehog Signaling in Cerebellar Development and Cancer
Frontiers in Cell and Developmental Biology, 2022 The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors.
Wanchen Wang +3 more
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A mathematical model of the role of aggregation in sonic hedgehog signalling.
PLoS Computational Biology, 2021 Effective regulation of the sonic hedgehog (Shh) signalling pathway is essential for normal development in a wide variety of species. Correct Shh signalling requires the formation of Shh aggregates on the surface of producing cells.
Daniel J A Derrick +3 more
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Investigation of the SHH gradient during limb development through quantitation of transcriptional regulation, expression, and protein distribution [PDF]
, 2015 Correct number and pattern of digits is determined in a time and concentration-dependent manner by a gradient of Sonic Hedgehog (SHH) across the anterior-posterior axis of the embryonic limb bud.
Johnson, Edward James
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Sonic hedgehog expression in the postnatal brain
Biology Open, 2019 Beyond its role in patterning the neural tube during embryogenesis, additional functions of Sonic hedgehog (Shh) in post-embryonic and mature brains have been coming into focus. However, the question of the abundance of endogenous Shh – the ligand of the
Aileen Rivell +6 more
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Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage. [PDF]
PLoS ONE, 2013 This study examines the regulating effect of Sonic Hedgehog (Shh) on the permeability of the blood-brain barrier (BBB) in cerebral ischemia. By employing permanent middle cerebral artery occlusion (pMCAO) model, we find that Shh significantly decreases ...
Yuan-peng Xia +10 more
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