Results 21 to 30 of about 74,513 (285)
Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia
Nature Communications, 2019 Central Anatolia harbored some of the earliest farming societies outside the Fertile Crescent of the Near East. Here, the authors report and analyze genome-wide data from a 15,000-year-old Anatolian hunter-gatherer and from seven Anatolian and Levantine ...
Michal Feldman +17 more
doaj +1 more source
Translational selection on SHH genes [PDF]
Genetics and Molecular Biology, 2010 Codon usage bias has been observed in various organisms. In this study, the correlation between SHH genes expression in some tissues and codon usage features was analyzed by bioinformatics. We found that translational selection may act on compositional features of this set of genes.
Hajjari, Mohammadreza +2 more
openaire +5 more sources
Genome-wide identification of Hand2 target regions in mouse embryos using dRMCE, a new genetic tool [PDF]
, 2012 Limb bud development is a paradigmatic model to study the molecular signals that orchestrate cell growth and behaviour. Anterior-posterior patterning of the limb bud mesenchyme is dependent on the secreted ligand Sonic hedgehog (Shh).
Osterwalder, Marco
core +1 more source
Disease Models & Mechanisms, 2019 Cleft palate (CP) is one of the most common congenital craniofacial anomalies in humans and can be caused by either single or multiple genetic and environmental factor(s).
Qi Wang +5 more
doaj +1 more source
SHH Pathway and Cerebellar Development [PDF]
The Cerebellum, 2009 The morphogenetic factor Sonic hedgehog (SHH) has been discovered as one of the masterplayers in cerebellar patterning and was subjected to intensive investigation during the last decade. During early postnatal development, this continuously secreted cholesterol-modified protein drives the expansion of the largest neuronal population of the brain, the ...
Vaillant C, Monard D
openaire +3 more sources
Identification of a Specific Vimentin isoform that Induces an Antibody Response in Pancreatic Cancer
Biomarker Insights, 2006 Pancreatic cancer has a poor prognosis, in part due to lack of early detection. The identification of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis.
Su-Hyung Hong +10 more
doaj +1 more source
Cell Death and Disease, 2023 Sonic hedgehog (Shh)-group medulloblastoma (MB) (Shh-MB) encompasses a clinically and molecularly distinct group of cancers originating from the developing nervous system with aberrant high Shh signaling as a causative driver.
Yuwei Li +9 more
doaj +1 more source
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups [PDF]
Acta Neuropathologica, 2011 Medulloblastoma is heterogeneous, being characterized by molecular subgroups that demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling pathway characterizes two of these molecular subgroups, the former associated with low-risk disease and the latter potentially targeted by novel SHH pathway inhibitors.
Ellison DW +13 more
openaire +4 more sources
Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. [PDF]
PLoS ONE, 2010 BACKGROUND: Microparticles (MPs) are vesicles released from plasma membrane upon cell activation and during apoptosis. Human T lymphocytes undergoing activation and apoptosis generate MPs bearing morphogen Shh (MPs(Shh+)) that are able to regulate in ...
Tarek Benameur +4 more
doaj +1 more source
Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells [PDF]
Journal of Cell Science, 2014 ABSTRACTAll morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to the surface of the cell in which they were produced. Thus, Hh release into the extracellular space requires accessory protein activities.
Petra, Jakobs +10 more
openaire +2 more sources