Results 11 to 20 of about 161,774 (219)

Enhancing Checkpoint Inhibitor Therapy in Solid Tissue Cancers: The Role of Diet, the Microbiome & Microbiome-Derived Metabolites

Frontiers in Immunology, 2021
Host immunity plays a central role in the regulation of anti-tumour responses during checkpoint inhibitor therapy (CIT). The mechanisms involved in long lasting remission remain unclear.
Agnieszka Beata Malczewski, Agnieszka Beata Malczewski, Agnieszka Beata Malczewski, Natkunam Ketheesan, Jermaine I. G. Coward, Jermaine I. G. Coward, Severine Navarro, Severine Navarro   +7 more
doaj   +1 more source

In Vitro and In Vivo Digestion of Persimmon and Derived Products: A Review

Foods, 2021
The link between nutrition and health has focused on the strategy of diet-based programs to deal with various physiological threats, such as cardiovascular disease, oxidative stress, and diabetes.
Cristina M. González, Isabel Hernando, Gemma Moraga   +2 more
doaj   +1 more source

Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High Fat Diets

Frontiers in Endocrinology, 2016
Low bone mass is often associated with increased bone marrow adiposity. Since osteoblasts and adipocytes are derived from the same mesenchymal stem cell progenitor, adipocyte formation may increase at the expense of osteoblast formation.
Laurence B Lindenmaier, Kenneth A Philbrick, Adam J Branscum, Satya P. Kalra, Russell T Turner, Russell T Turner, Urszula T Iwaniec, Urszula T Iwaniec   +7 more
doaj   +1 more source

Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3

Scientific Reports, 2022
Nonalcoholic fatty liver disease (NAFLD) is associated with increased oxidative stress that leads to hepatocyte and mitochondrial damage. In this study we investigated the mechanisms involved in the induction of oxidative stress and impairment of ...
Simon Musyoka Mwangi, Ge Li, Arun Balasubramaniam, Didier Merlin, Paul A. Dawson, Young C. Jang, C. Michael Hart, Mark J. Czaja, Shanthi Srinivasan   +8 more
doaj   +1 more source

Treating Diet-Induced Diabetes and Obesity with Human Embryonic Stem Cell-Derived Pancreatic Progenitor Cells and Antidiabetic Drugs

Stem Cell Reports, 2015
Human embryonic stem cell (hESC)-derived pancreatic progenitor cells effectively reverse hyperglycemia in rodent models of type 1 diabetes, but their capacity to treat type 2 diabetes has not been reported. An immunodeficient model of type 2 diabetes was
Jennifer E. Bruin, Nelly Saber, Natalie Braun, Jessica K. Fox, Majid Mojibian, Ali Asadi, Campbell Drohan, Shannon O’Dwyer, Diana S. Rosman-Balzer, Victoria A. Swiss, Alireza Rezania, Timothy J. Kieffer   +11 more
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Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model.

PLoS ONE, 2015
IntroductionNeuroblastoma is a malignant pediatric cancer derived from neural crest cells. It is characterized by a generalized reduction of mitochondrial oxidative phosphorylation.
Raphael Johannes Morscher, Sepideh Aminzadeh-Gohari, René Gunther Feichtinger, Johannes Adalbert Mayr, Roland Lang, Daniel Neureiter, Wolfgang Sperl, Barbara Kofler   +7 more
doaj   +1 more source

Can the ketogenic diet improve the hamstring muscle rupture? A narrative review [PDF]

Journal of Sports and Rehabilitation Sciences
The ketogenic diet has garnered significant attention for its potential benefits in various health areas, including weight loss, neurological conditions, and metabolic diseases.
Saeid Emamdoost
doaj   +1 more source

Incorporation of Plant-Based Diet Surpasses Current Standards in Therapeutic Outcomes in Inflammatory Bowel Disease

Metabolites, 2023
There has been no study of the therapeutic effect of a plant-based diet (PBD) in inflammatory bowel disease (IBD) except for our studies in Japan.
Mitsuro Chiba, Norikazu Morita
doaj   +1 more source

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms

Frontiers in Neurology, 2019
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation and usually produced in fasting state or on high-fat diets have broad neuroprotective effects.
Huajun Yang, Huajun Yang, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Fei Zhu, Fei Zhu, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang, Qun Wang   +14 more
doaj   +1 more source

Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy

iScience, 2020
Summary: Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy.
Jantzen Sperry, Michael C. Condro, Lea Guo, Daniel Braas, Nathan Vanderveer-Harris, Kristen K.O. Kim, Whitney B. Pope, Ajit S. Divakaruni, Albert Lai, Heather Christofk, Maria G. Castro, Pedro R. Lowenstein, Janel E. Le Belle, Harley I. Kornblum   +13 more
doaj   +1 more source