Results 91 to 100 of about 4,549,733 (400)

Independent and combined associations between fast-food outlet exposure and genetic risk for obesity: a population-based, cross-sectional study in the UK

BMC Medicine, 2021
Background Characteristics of the built environment, such as neighbourhood fast-food outlet exposure, are increasingly recognised as risk factors for unhealthy diet and obesity.
Thomas Burgoine, Pablo Monsivais, Stephen J. Sharp, Nita G. Forouhi, Nicholas J. Wareham   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Comparison and effect of plain and calcium fortified yogurt on glycemic responses, anthropometrics and metabolic biomarkers

Immunological Medicine
Metabolic syndromes including obesity and diabetes are the most common health issues due to insulin resistance, disturbance in glucose homeostasis, lack of exercise, and improper diet.
Asma Draz, Hafiza Madiha Jaffar, Bahisht Rizwan, Sadia Sukhera, Syeda Aiman Batool, Sana Noreen, Nazia Koser, Zeenat Islam   +7 more
doaj   +1 more source

Adaptive Data Synchronization Algorithm for IoT-Oriented Low-Power Wide-Area Networks

Sensors, 2018
The Internet of Things (IoT) is by now very close to be realized, leading the world towards a new technological era where people’s lives and habits will be definitively revolutionized.
Andrea Petroni, Francesca Cuomo, Leonisio Schepis, Mauro Biagi, Marco Listanti, Gaetano Scarano   +5 more
doaj   +1 more source

Sulphur-isotope compositions of pig tissues from a controlled feeding study [PDF]

, 2017
Sulphur-isotope determinations are becoming increasingly useful for palaeodietary reconstruction, but knowledge of isotopic discrimination between diet and various tissues remains inadequate. In this study, we explore the sensitivity of δ34Stissue values
Evershed, Richard P., Lewis, Jamie, Miller, Bevis, Newton, Jason, Stewart, Alan, Tarlton, John F., Webb, Emily C.   +6 more
core   +2 more sources

Effects of arginine and ornithine supplementation to a high‐protein diet on selected cellular immune variables in adult cats [PDF]

, 2020
Background: Dietary protein and amino acid intake and composition can modulate immune function. Objectives: To evaluate the effects of high‐protein intake and arginine and ornithine supplementation on feline immune cells.
Kohn, Barbara, Paßlack, Nadine, Zentek, Jürgen   +2 more
core   +1 more source

The gut microbiota at the intersection of diet and human health

Science, 2018
Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease.
C. Gentile, T. Weir
semanticscholar   +1 more source

Diet, Stress and Mental Health

Nutrients, 2020
Introduction: There has long been an interest in the effects of diet on mental health, and the interaction of the two with stress; however, the nature of these relationships is not well understood.
J. Bremner, K. Moazzami, M. Wittbrodt, J. Nye, Bruno B. Lima, Charles F. Gillespie, M. Rapaport, B. Pearce, Amit J. Shah, V. Vaccarino   +9 more
semanticscholar   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source