Results 311 to 320 of about 4,549,733 (400)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Cecal microbiota of broilers responds similarly to black soldier fly larvae fat and conventional dietary fat sources. [PDF]

PLoS One
Aslam MR, Kierończyk B, Szymkowiak P, Ciesielska L, Rawski M, Mikuła R, Józefiak D.   +6 more
europepmc   +1 more source

Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex

, 2016
Jesse L. Carlin, Nicola M. Grissom, Zhe Ying, Fernando Gómez‐Pinilla, Teresa M. Reyes   +4 more
openalex   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Oral health indices and microbiota populations of adult cats consuming wet or dry diets. [PDF]

Front Vet Sci
Oba PM, Swanson OR, Pavlovsky G, Dupleix CR, Sharping SCJ, Swanson KS.   +5 more
europepmc   +1 more source

Long non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity

, 2017
Tian An, Teng Zhang, Fei Teng, Jiacheng Zuo, Yanyun Pan, Yufei Liu, Jianan Miao, Yujie Gu, Na Yu, Dandan Zhao, Fangfang Mo, Si‐Hua Gao, Guangjian Jiang   +12 more
openalex   +2 more sources

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

A vegan diet signature from a multi-omics study on different European populations is related to favorable metabolic outcomes. [PDF]

Gut Microbes
Ouradova A, Ferrero G, Bratova M, Daskova N, Bohdanecka A, Dohnalova K, Heczkova M, Chalupsky K, Kralova M, Kuzma M, Modos I, Tichanek F, Najmanova L, Pardini B, Pelantová H, Tarallo S, Videnska P, Gojda J, Naccarati A, Cahova M.   +19 more
europepmc   +1 more source

Forelimb Motor Learning and Memory Consolidation Drives Distinct Oligodendrocyte Plasticity to Regulate Task‐related Neuronal Activity

Advanced Science, EarlyView.
Genetic and chemical tracking of oligodendrogenesis, combining fiber photometric neuronal activity recording, reveals that distinct oligodendrocyte plasticities are adopted during different phases of motor learning to fine‐tune task‐related neuronal activity, with a preferential involvement of oligodendrogenesis suppression and node lengthening (type 2
Shuming Wang, Nuo Xu, Wenwen Wang, Yongxiang He, Yuqian Yang, Liuning Zhang, Yanping Zou, Yuehua He, Huiliang Li, Liang Gao, Lin Xiao   +10 more
wiley   +1 more source

A qualitative evaluation of older people's perceptions towards optimal diet management in the context of antimicrobial resistance. [PDF]

BMC Public Health
Flintham L, Dack C, Koumanov F, Feil E, Ainsworth B.   +4 more
europepmc   +1 more source