Results 321 to 330 of about 4,549,733 (400)

Deoxynivalenol Exposure Leads to Abnormal Renal Tubular Autophagy Flow

Advanced Science, EarlyView.
DON exposure disrupts the initiation of renal autophagy by inhibiting the formation of autophagosomes, thereby impairing mitochondrial degradation. Damaged mitochondria increase oxidative stress, reduce ferroptosis resistance, and cause lysosomal Fe2⁺ accumulation, further disrupting autophagy.
Hao Chen, Xintong Zhou, Jun Ma
wiley   +1 more source

The Effect of a Low-Energy and Low-Glycemic Diet on Adipose Tissue Metabolism and Energy Expenditure in Women with Excess Body Weight. [PDF]

Nutrients
Lange E, Pałkowska-Goździk E.
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Dietary supplementation with Bacillus-based probiotic improves gut health in the weaned piglets challenged by rotavirus. [PDF]

J Anim Sci Biotechnol
Xiang F, Yang H, Fan X, Tan D, Huang B, Yu B, He J, Luo Y, Luo J, Yan H, Pu J, Wang J, Wang Q, Wang H, Htoo JK, Mendoza SM, Yan G, Mao X.   +17 more
europepmc   +1 more source

Microbial Community Succession Sustains Fish Diversity in the Upper Yangtze River Reserve

Advanced Science, EarlyView.
Critical for river ecosystem sustainability, fish diversity relates to multitrophic microbes. This upper Yangtze FNNR study used eDNA to examine microbial succession‐fish links, finding key drivers, distinct assembly processes, and that microbial cross‐trophic interactions benefit fish, offering conservation insights.
Jiaxin Huang, Xiaohan Dong, Xinxin Zhou, Zongqiang Qi, Ziwei Wang, Jiali Ran, Kaiyue Xiao, Xingyu Pan, Hong Chen, Zhihao Liu, Qiliang Chen, Huajun Yang, Yanjun Shen   +12 more
wiley   +1 more source

Association between EAT-Lancet diet adherence and incident type 2 diabetes in Shanghai adults: a prospective cohort study. [PDF]

BMC Public Health
Xu X, Zhao G, Liu X, Liu X, Xu H, Jiang Y, Peng Q, Shi J, He D, Zhou Y, He M.   +10 more
europepmc   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

The Mediterranean Diet in Primary and Secondary Prevention of Coronary Heart Disease: Evidence and Mechanisms. [PDF]

Nutrients
Młynarska E, Kurcińska J, Kurciński S, Marcinkowska W, Leszto K, Jakubowska P, Rysz J, Franczyk B.   +7 more
europepmc   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Association of the dietary anti-oxidant index with inflammatory marker such as interleukin-6 in women with and without polycystic ovarian syndrome: a comparative case‒control study. [PDF]

BMC Nutr
Azarbayjani K, Sadatmahalleh SJ, Mottaghi A, Nasiri M.   +3 more
europepmc   +1 more source