Results 231 to 240 of about 1,897,565 (264)

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

From Harvest to Health: A Systems-Based Evaluation of FarmsSHARE's Impact on Nutrition in North Carolina. [PDF]

J Hum Nutr Diet
Hege A, Schier H, Grant J, Walker D, McCann M.   +4 more
europepmc   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

How can the use of different modes of survey data collection introduce bias? An introduction to mode effects using directed acyclic graphs (DAGs). [PDF]

Am J Epidemiol
Tomova GD, Silverwood RJ, Tennant PWG, Wright L.   +3 more
europepmc   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Rethinking Restrictive Diets in IBD: Toward an Inclusion-Focused Nutritional Paradigm. [PDF]

Curr Gastroenterol Rep
Cunha B, Alter A, Berschback M, Park S, Gold S, Schneider Y.   +5 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults. [PDF]

Aging Cell
Beydoun MA, Fanelli Kuczmarski MT, Noren Hooten N, Beydoun HA, Tsai J, Maldonado AI, Hossain S, Nieva A, Evans MK, Zonderman AB.   +9 more
europepmc   +1 more source

Participant food tracking in psychiatric ketogenic metabolic therapy: an unresolved clinical, psychosocial, and implementation question. [PDF]

Front Nutr
Laurent N.
europepmc   +1 more source

Exploratory Evaluation of a Medical Student-Led Health Literacy Program Among High School Students. [PDF]

J Sch Health
Carey NL, Johnson I, Ruff A, Finks JF.
europepmc   +1 more source