Results 161 to 170 of about 244,820 (280)

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

open access: yesAngewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou   +8 more
wiley   +2 more sources

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen   +12 more
wiley   +1 more source

Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron. [PDF]

open access: yesNat Commun
Gal-Mandelbaum N   +8 more
europepmc   +1 more source

Glycemic Index (GI) Values for Major Sources of Dietary Carbohydrates in Iran. [PDF]

open access: yesInt J Endocrinol Metab, 2020
Kazemi F   +8 more
europepmc   +1 more source

Establishment of a novel cynomolgus monkey model of hyperuricemia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang   +12 more
wiley   +1 more source

The association between hypertension and different types of dietary carbohydrates. [PDF]

open access: yesCardiovasc Endocrinol Metab
Rafieipour A   +13 more
europepmc   +1 more source

Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity. [PDF]

open access: yesAm J Physiol Endocrinol Metab, 2020
Her TK   +5 more
europepmc   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud   +3 more
wiley   +1 more source

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