Results 241 to 250 of about 289,473 (283)

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Adapting the Dietary Fat and Free Sugar Short Questionnaire: A Comprehensive Polish Modification for Enhanced Precision in Nutritional Assessments. [PDF]

Nutrients
Tabiś K, Maćków M, Nowacki D, Poprawa R.   +3 more
europepmc   +1 more source

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation

Advanced Science, EarlyView.
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin, Wenjuan Tang, Danqing Huang, JingJing Gan, Pengzi Zhang, Yuanjin Zhao, Yan Bi   +6 more
wiley   +1 more source

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

Advanced Science, EarlyView.
This review summarizes recent advances in the spatiotemporal dynamics of the tumor microenvironment (TME). It highlights the roles of diverse immune and stromal cell populations, spatial architecture of the TME, as well as the gut and tumor microbiota in influencing responses to immune checkpoint inhibitors (ICIs), by integrating insights from single ...
Yuanyuan Zhang, Zhihua Liu
wiley   +1 more source

Graphitized Biochar Derived from Agricultural Wastes Enhances Methanogenesis via Conductivity‐Driven Direct Interspecies Electron Transfer

Advanced Science, EarlyView.
This work clarifies how feedstocks and their structural features promote methanogenesis, and identifies the key regulatory factors, reducing pollution to the global environment, and also helps to alleviate the energy crisis. This is the first study to systematically link feedstock lignin content, pyrolysis conditions, biochar graphitization, and DIET ...
Caiyun Yang, Zhen Liu, Weiguo Liu, Yuxin Qiu, Shuai Zhang, Xinke Zhang, Mengyi Wang, Heng Wu, Hongyi Lyu, Jinzhi Huang, Jia Liu, Yirong Wang, Siying He, Dongze Gu, Xiaohui Guo, Xuanmin Yang, Teng Xie, Heyu Chen, Yiqing Yao   +18 more
wiley   +1 more source

Hyperspectral Fluorescence Imaging with a New Polarity‐Ultrasensitive Fluorescent Probe

Advanced Science, EarlyView.
Based on the critical role of the π‐spacer in determining wavelength sensitivity to microenvironmental polarity, a new fluorescent probe, Lipi‐PS is rationally developed, which exhibits the highest polarity‐sensitivity so far. Its integration with hyperspectral fluorescence imaging enables multiscale polarity mapping across cells, tissues, and ...
Ri Zhou, Hao Sha, Shengjie Fu, Guannan Liu, Jinbei Wei, Chenguang Wang, Shangguo Hou, Geyu Lu   +7 more
wiley   +1 more source

Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice. [PDF]

Nat Commun
Huang Y, Wang A, Zhou W, Li B, Zhang L, Rudolf AM, Jin Z, Hambly C, Wang G, Speakman JR.   +9 more
europepmc   +1 more source

Rational Design of Advanced Functional Catalysts for Photo‐Reforming Glucose into Bio‐Derived Fuels and Chemicals

Advanced Science, EarlyView.
This review systematically summarizes the fundamental mechanisms of photocatalytic glucose conversion, catalyst design strategies, key reaction pathways, structure‐activity relationships, influence of reaction parameter adjustments, and current challenges in the field.
Qiong Yan, Yuyue Zhou, Yan Zhang, Dalin Sun, Xu Wu, Song Yang, Chunbao Xu, Heng Zhang   +7 more
wiley   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science, EarlyView.
In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
wiley   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source