Results 271 to 280 of about 173,728 (337)

SLC6A14 Drives Mitochondrial Fusion and Oxidative Phosphorylation to Promote Cancer Stemness and Early‐Onset of Breast Cancer

Advanced Science, EarlyView.
Elevated levels of the plasticizer DEHP associate with earlier breast cancer diagnosis. DEHP enhances glutamine‐powered energy production via the transporter SLC6A14 and pushes mitochondria toward fusion, driving tumor initiation by boosting cancer stemness. Blocking SLC6A14 lowers stemness, slows tumors, and improves chemotherapy response.
Dai‐Wei Hu, Chih‐Hao Huang, Yu‐Hao He, Ya‐Ling Wei, Shu‐Wei Hu, Fang‐Ju Cheng, Thanh Kieu Huynh, Bo‐Rong Chen, Bo‐Wei Wang, Li‐Chi Kuan, Der‐Yen Lee, Ming‐Hsin Yeh, Ya‐Jen Chang, Liang‐Chih Liu, Mien‐Chie Hung, Wei‐Chien Huang   +15 more
wiley   +1 more source

Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases

Advanced Science, EarlyView.
This study analyzes 398 432 participants, identifying four distinct metabolic‐inflammatory subtypes. These subtypes show a significant association with digestive disease risk. Cluster‐associated metabolite signatures partially explain this link. Machine learning models using these metabolites accurately predict risk for ten digestive diseases. Key risk
Zhenhe Jin, Qichen Chen, Liangfeng Zhou, Kexin Ye, Zhaoxue Liu, Wenxi Jiang, Linwen Luo, Yize Wang, Xiaohua Ye, Chaohui Yu, Zhe Shen   +10 more
wiley   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

The interactive impact of dietary PUFA on the deposition of DHA in the egg yolk [PDF]

, 2007
Delezie, Eveline, Huyghebaert, Gerard, Raes, Katleen, Maertens, Luc, Arnouts, Sven   +4 more
core   +1 more source

Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota

Advanced Science, EarlyView.
Non‐invasive photobiomodulation therapy (PBMT) enhances muscle endurance by rewiring the gut‐muscle axis. PBMT preserves gut epithelial integrity and enriches beneficial anaerobes, driving metabolites such as butyrate, spermidine, and L‐carnitine that supercharge mitochondrial energy in skeletal muscles.
Prabhat Upadhyay, Asmita Banstola, Brijesh Bhayana, Mei X. Wu   +3 more
wiley   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

Advanced Science, EarlyView.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou, Chunsong Wang, Jieying Gao, Xu Wu, Geng Li, Xuejun Jiang, Yinyin Xia, Jun Zhang, Bo Lv, Feng Zhao, Hongyang Zhang, Huifeng Pi, Jingfu Qiu, Shangcheng Xu, Zhen Zou, Chengzhi Chen   +15 more
wiley   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

Advanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park, Min‐Ji Kim, Jae‐Ho Shin, Eunsoo Kim, Myeongjoo Son, Seungjun Lee   +5 more
wiley   +1 more source