Results 121 to 130 of about 284,697 (290)

Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]

, 2003
The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core   +2 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Functional properties and optimization of dietary fiber concentrate from sago hampas using response surface methodology

Journal of Agriculture and Food Research
Sago hampas, whose major components are fiber and starch, is an underutilized by-product generated from starch extraction of sago stems. In order to increase its added value and applications, sago hampas could be developed into dietary fiber concentrate.
Yanuar Sigit Pramana, Karjawan Pudjianto, Arni Supriyanti, Sarah Elisa, Derina Paramitasari, Mardonius Budi Kusarpoko, Eka Nurazmi Yunira, Sabirin Sabirin, Agus Eko Tjahjono, Dyah Primarini Meidiawati, Okta Nama Putra, Noer Abyor Handayani   +11 more
doaj   +1 more source

Does a high-fiber diet prevent colon cancer in at-risk patients? [PDF]

, 2003
There is no direct evidence of an effect of dietary fiber on colon cancer incidence. A diet high in fiber has not been shown to be effective in the short-term (2- to 4-year) prevention of recurrent colon polyps (strength of recommendation [SOR]=A, based ...
French, Linda, Kendall, Susan K.
core  

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Impact of High-pressure Homogenization on the Physical Properties and Structure of Dietary Fiber from Pea Hull

Liang you shipin ke-ji
This study investigated the effects of initial particle size, homogenization pressure, and solid-to-liquid ratio on the generation of water-soluble dietary fiber (SDF), particle size, surface microstructure, and crystal structure of pea hull dietary ...
ZHANG You-min, LI Su-fen, REN Shi-xin, LI Yuan-da, LIU Jian-fu   +4 more
doaj   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

The moderating effect of dietary fiber intake on the association between sleep pattern and liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES

BMC Gastroenterology
Background Insufficient nocturnal sleep was associated with a higher risk of fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Guoqing Jia, Mengzhen Jia, Chuntao Li
doaj   +1 more source

Differential Relationship between Physical Activity and Intake of Added Sugar and Nutrient-Dense Foods: A Cross-Sectional Analysis [PDF]

, 2019
A curvilinear relationship exists between physical activity (PA) and dietary energy intake (EI), which is reduced in moderately active when compared to inactive and highly active individuals, but the impact of PA on eating patterns remains poorly ...
Bice, Matthew R., Boron, Julie B., Garvin, Teresa M., Koehler, Karsten, Stevens, Jeffrey R.   +4 more
core   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source