Results 51 to 60 of about 1,397,833 (299)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Inflammation mediated the effect of dietary fiber on depressive symptoms
Frontiers in Psychiatry, 2023 Background and aimsPrevious studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms.
Ting Zhang +11 more
doaj +1 more source
Analysis of in vitro binding of dietary fibers by the phytoestrogen, daidzein, in the presence and absence of iron [PDF]
, 2000 Plan BThe concentration of unbound daidzein, a phytoestrogen, found in soy products, was measured by high performance liquid chromatography in solutions containing insoluble (cellulose) and soluble (locust bean gum) dietary fibers in vitro.
Dinauer, Christina Marie
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Nippon Shokuhin Kagaku Kogaku Kaishi, 2011 繊維質とは，自然に放置しても分解されにくく，動物によっても消化されにくい成分のことを指す．本来，ヒトの消化酵素で消化されない繊維質は，生理的意義が低い非栄養素とされてきたが，難消化性の繊維質はヒトの健康維持に重要な役割を果たすことが次第に知られるようになった．食物繊維とは多糖類のひとつであるが，日本食品標準成分表2010では「ヒトの消化酵素で消化されない食品中の難消化性成分の総体」と定義されている．ヒトの炭水化物消化酵素であるアミラーゼは，デンプンを構成している糖分子のα結合を分解できるが，食物繊維を形成しているβ結合を分解する能力がない．従来，食物繊維はエネルギー源にならないと考えられていたが，実際は，消化されない食物繊維の一部が腸内細菌により発酵分解されて短鎖脂肪酸とガスになるため ...
openaire +2 more sources
Do Soup Kitchen Meals Contribute to Suboptimal Nutrient Intake & Obesity in the Homeless Population? [PDF]
, 2011 The double burden of suboptimal nutrient intake and obesity exists when available foods lack essential nutrients to promote health and provide high amounts of energy.
Lisa G. Sisson +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2021 Dietary fibers have become increasingly popular in recent years with various applications in the food and pharmaceutical industry industries. Dietary fibers are plant-based foods which are incompletely digested by digestive enzymes.
Ana Maria Pah +9 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source