Results 81 to 90 of about 34,264 (221)

Variation and development of the turtle chondrocranium, with a description of the common musk turtle (Sternotherus odoratus, Kinosternidae, Cryptodira, Testudines)

The Anatomical Record, EarlyView., 2023
Abstract Based on histological cross‐sections, the chondrocranium of the common musk turtle (Sternotherus odoratus) was reconstructed, described, and compared with other turtles. It differs from that of other turtle chondrocrania by possessing elongated, slightly dorsally orientated nasal capsules with three dorsolateral foramina, which might be ...
Luca Leicht, Zitong Zhang, Ingmar Werneburg   +2 more
wiley   +1 more source

Burn‐Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan‐Kynurenine Mediated AHR Pathway Activation

Advanced Science, EarlyView.
This study elucidates a pivotal crosstalk between the gut microbiota and skeletal muscles atrophy induced by burn injuries, a process fueled by the overactivation of IDO‐1 in the colon. This overactivation initiates the metabolism of tryptophan into kynurenine.
Shan Gao, Yan Leng, Zhen Qiu, Kai Li, Jun Li, Jian Peng, Weiguo Xie, Shaoqing Lei, Zhongyuan Xia   +8 more
wiley   +1 more source

Oral Microalgae‐Based Biosystem to Enhance Irreversible Electroporation Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study presents an innovative oral microalgae‐based biosystem to inhibit tumor growth, reduce PD‐1 expression, and activate immune responses of hepatocellular carcinoma. When combined with enhanced irreversible electroporation treatment, it demonstrates a synergistic effect that effectively reduces the tumor burden and enhances the tumor immune ...
Cheng Zeng, Shiyuan Hua, Jiayu Zhou, Tangye Zeng, Jianke Chen, Lijian Su, Angfeng Jiang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via 68Ga‐FAPI‐04 PET Imaging

Advanced Science, EarlyView.
[68Ga]‐FAPI‐04 PET imaging technique represents a potential method to assess the extent of AA remodeling in vivo and may help to identify candidates at potential risk for rapid AA progression. Abstract Traditional imaging modalities used to monitor the diameter of aortic aneurysms (AAs) often fail to follow pathological progression.
Chengkai Hu, Hui Tan, Yuchong Zhang, Genmao Cao, Chenye Wu, Peng Lin, Shouji Qiu, Fandi Mo, Enci Wang, Shiyi Li, Tong Yuan, Zheyun Li, Weiguo Fu, Dengfeng Cheng, Hao Lai, Xiaoyuan Chen, Lixin Wang   +16 more
wiley   +1 more source

Targeting the Adenosine‐Mediated Metabolic Immune Checkpoint with Engineered Probiotic for Enhanced Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study presents engineered probiotics that convert immunosuppressive adenosine into inosine in tumors, alleviating immunosuppression and enhancing antitumor immunity. Demonstrating efficacy in murine ectopic and orthotopic tumor models, this approach offers a promising probiotic‐based cancer immunotherapy strategy, highlighting the potential of ...
Jinhui Wang, Jing Wang, Zhijie Yu, Hongyu Wen, Chensi Zhao, Jiayong Zhong, Chuanle Xiao, Yingqiu Li, Jianqiao Xu, Jinquan Wang, Zong‐Wan Mao, Wei Xia   +11 more
wiley   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

Advances in Fecal Microbiota Transplantation for Gut Dysbiosis‐Related Diseases

Advanced Science, EarlyView.
This article reviews the use of fecal microbiota transplantation (FMT) to treat intestinal diseases like recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), and irritable bowel syndrome (IBS). It discusses FMT's efficacy, influencing factors such as donor selection, recipient characteristics, and treatment protocols ...
Shuna Hou, Jiachen Yu, Yongshuang Li, Duoyi Zhao, Zhiyu Zhang   +4 more
wiley   +1 more source

The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus

Advanced Science, EarlyView.
Large‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia‐Shigella in patients with T2DM‐related‐ASCVD, which correlates with their
Yao‐Yuan Zhang, Song‐Tao Chen, Gang Chen, Le Zhou, Guo‐Liang Zhou, Xin‐Yuan Yu, Long Yuan, Wei‐Qian Deng, Zhen‐Bo Wang, Jing Li, Yi‐Fu Tu, Da‐Wei Zhang, Yuan li, Abdul Sammad, Xiao Zhu, Kai Yin   +15 more
wiley   +1 more source

Extracellular Vesicle‐Packaged Linc‐ZNF25‐1 from Pancreatic Cancer Cell Promotes Pancreatic Stellate Cell Uptake of Asparagine to Advance Chemoresistance

Advanced Science, EarlyView.
This study explores the role of gemcitabine (GEM)‐resistant pancreatic cancer‐derived extracellular vesicles (EVs) in activating pancreatic stellate cells (PSCs) and promoting extracellular matrix production. GEM‐resistant cells release higher levels of asparagine (Asn), which triggers PSC activation. Long noncoding RNA sequencing identified linc‐ZNF25‐
Miao Yu, Mingxin Su, Zhenfeng Tian, Lele Pan, Zongmeng Li, Enlai Huang, Yinting Chen   +6 more
wiley   +1 more source