Results 51 to 60 of about 156,514 (228)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Association Between the Children's Dietary Inflammatory Index (C-DII) and Markers of Inflammation and Oxidative Stress Among Children and Adolescents: NHANES 2015-2018

Frontiers in Nutrition, 2022
ObjectivesTo explore the association of Children's Dietary Inflammatory Index (C-DII) scores with inflammation and markers of inflammatory factors in children and adolescents.MethodsData on dietary nutrient intake, markers of inflammation (ferritin ...
Chuang Zhang, Weirui Ren, Meng Li, Wenbo Wang, Chi Sun, Lin Liu, Yanbin Fang, Lin Liu, Xiaofeng Yang, Xiangjian Zhang, Suolin Li   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Diet-induced inflammation and its association with sarcopenia in an Iranian population: a case-control study

Journal of Health, Population and Nutrition
Background Dietary intake, as one of the critical lifestyle risk factors, plays a crucial role in the risk of sarcopenia, potentially due to its anti-inflammatory properties. The objective of this study was to evaluate the association between the Dietary
Neda Heidarzadeh-Esfahani, Sevda Eskandarzadeh, Marzieh Mahmoodi, Maede Makhtoomi, Seyyed Mohammad Alavi, Zainab Shateri, Nasrin Nasimi, Mehran Nouri, Mohammad Hossein Dabbaghmanesh   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Anti-inflammatory diets might mitigate the association between sedentary behaviors and the risk of all-cause deaths

Nutrition & Metabolism
Background and aims The pathogenic mechanism of sedentary behavior involves chronic inflammation, which can be affected by dietary inflammation. This study aimed to determine the association between dietary inflammation, sedentary behavior, and risk of ...
Haixu Wang, Zeming Zhou, Xiaoxin Liu, Ying Chen   +3 more
doaj   +1 more source

Associations Between Dietary Habits and Accelerated Aging and the Establishment of an Accelerated Aging Interpretable Risk Prediction Model via Shapley Additive Explanations: Cross-Sectional Study From Two Representative Populations

JMIR Aging
BackgroundResearch has revealed potential links between specific dietary habits and accelerated aging. However, most studies focus only on singular diets or lack ethnic diversity.
Zhengyang Wu, Ning Zhang, Haiwei Wang, Yang Yang, Houhao Shen, Qidi Zhang, Yunxia Cao, Yinan Du, Dongmei Ji   +8 more
doaj   +1 more source

A higher dietary inflammatory index score is associated with a higher risk of incidence and mortality of cancer: A comprehensive systematic review and meta-analysis

International Journal of Preventive Medicine, 2020
Background: Inflamation is widely known as an adaptive pathophysiological response in a variety of cancers. There is an expanding body of research on the key role of diet in inflammation, a risk factor for all types of cancer. Dietary inflammatory index (
Hoda Zahedi, Shirin Djalalinia, Hamid Asayesh, Morteza Mansourian, Zahra Esmaeili Abdar, Armita Mahdavi Gorabi, Hossein Ansari, Mehdi Noroozi, Mostafa Qorbani   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Association between Dietary Inflammation Index and Gestational Anemia in Pregnant Women under Different Dietary Patterns [PDF]

Zhongguo quanke yixue
Background According to WHO, 37% of pregnant women suffer from anemia. Anemia in pregnant women increases the risk of adverse pregnancy outcomes, with inflammatory anemia being particularly common. During pregnancy, the body experiences chronic low-grade
DONG Chenxian, SHAO Jianjiang, YAO Teng, ZHAI Jinchan, MA Jiaolong, HU Yunhua, LIU Wen, NIU Qiang, LI Xiaoju, YAN Yizhong
doaj   +1 more source