Results 101 to 110 of about 5,719,188 (264)

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Body mass index and insulin resistance in healthy adults: Associations with plasma osteocalcin, phylloquinone levels, and dietary vitamin K intake

, 2020
The skeletal system is considered an endocrine organ today. Associations between bone Gla proteins, body mass index and insulin resistance are intriguing novel field due to being possible explanations for the interactions between bone and endocrine ...
Akturk, Mujcle, Ertas-Orturk, Yasemin, Gezmen-Karadag, Makbule, Sanlier, Nevin   +3 more
core   +2 more sources

Dietary insulin load and index in relation to incident gestational diabetes mellitus: a prospective cohort study

Scientific Reports
No study has examined the association between dietary insulin load (DIL) and insulin index (DII) with developing gestational diabetes mellitus (GDM) during pregnancy.
Azadeh Aminianfar, Hamid Zolfaghari, Sanaz Soltani, Hossein Hajianfar, Leila Azadbakht, Zahra Shahshahan, Ahmad Esmaillzadeh   +6 more
doaj   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris

, 2016
Background. There is increasing evidence to support the relationship between acne vulgaris and diet. Objective. The aim of this study was to investigate possible associations among dietary glycemic index, glycemic load, milk consumption, insulin ...
Ozturk, Feyza Yener, Altunay, Ilknur Kivanc, Arici, Janset Erkul, Tulunay, Aysin, Aktas, Ezgi, Cerman, Asli Aksu   +5 more
core   +2 more sources

Influence of dietary insulin scores on survival in colorectal cancer patients

, 2017
BACKGROUND: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival.
Sato, K., Chen Yuan, Edward L Giovannucci, Yuan, C., Mingyang Song, Meir J Stampfer, Ng, K., Jeffrey A Meyerhardt, Walter C Willett, Bao, Y., Nimptsch, K., Wu, K., Brand-Miller, J.C., Kimmie Ng, Stampfer, M.J., Ying Bao, Willett, W.C., Song, M., Morales-Oyarvide, V., Jennie C Brand-Miller, Brian M Wolpin, Andrew T Chan, Kana Wu, Katharina Nimptsch, Charles S Fuchs, Meyerhardt, J.A., Kaori Sato, Keum, N., Vicente Morales-Oyarvide, NaNa Keum, Wolpin, B.M., Chan, A.T., Fuchs, C.S., Emilie S Zoltick, Giovannucci, E.L., Zoltick, E.S.   +35 more
core   +1 more source

FBP1‐Mediated Compartmentalization of Glycolytic Enzyme Complexes Suppresses PKM2 Function to Ameliorate MASLD Progression

Advanced Science, EarlyView.
In normal hepatocytes, FBP1 forms compartmentalized complexes with PKM2, ENO1, and LDHA independent of its catalytic activity, inhibiting PKM2 activity and restricting excessive glycolysis. During MASLD progression, FBP1 downregulation markedly reduces the abundance of these complexes and releases the “hijacked” glycolytic enzymes, leading to PKM2 ...
Busong Wang, Yiping Tang, Na Li, Xuening Dai, Jing Wu, Bin Xue, Yuxin Chen, Jingzi Zhang, Lingdong Kong, Chaojun Li, Lei Fang   +10 more
wiley   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Association between dietary inflammatory index (DII) and insulin resistance (HOMA-IR) in obese adults

AcTion: Aceh Nutrition Journal
The global rise in obesity, including in Semarang, Indonesia, has been associated with an increased risk of insulin resistance, which can be assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
Millennia Dorais Sinaga, Ninik Rustanti
doaj   +1 more source