Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis
Advanced Science, EarlyView.A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song +5 more
wiley +1 more source
Impact of high- and low-glycemic index diets on salivary insulin and cortisol: a scoping review
Padjadjaran Journal of DentistryIntroduction: Saliva is a complex biological fluid secreted by the body and has components that act as biomarkers indicating various health conditions.
Anargya Alfa Fairuz +2 more
doaj +1 more source
A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis
Advanced Science, EarlyView.Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee +7 more
wiley +1 more source
The relationship between body fat distribution, insulin sensitivity and postprandial lipids in Europeans and South Asians : a cross-sectional study. [PDF]
Metabolic disturbances associated with central obesity and insulin resistance might underlie the higher rates of diabetes and coronary heart disease in South Asians compared with Europeans.
Forouhi, Nita Gandhi
core +1 more source
Advanced Science, EarlyView.Regulation of WAT Browning and UCP1 Expression in LepR‐MSCs of Inguinal WAT by Nociceptive CGRP and Sympathetic Nervous System (SNS) Noradrenaline (NE). ABSTRACT Sympathetic innervation regulates white adipose tissue (WAT) browning; however, the roles of nociceptive neurons and their associated target cells remain unknown.
Yu‐Ting Yen +11 more
wiley +1 more source
Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults. [PDF]
Sci Rep, 2021 Abaj F, Rafiee M, Koohdani F.
europepmc +1 more source
Agribusiness, EarlyView.ABSTRACT Nutritional information is very important in the food choices of consumers. However, when they are too scientific or technical, they have the potential to confuse consumers, resulting in information asymmetry and dissuading them from making beneficial choices.
Edeoba W. Edobor +3 more
wiley +1 more source
The Association of Inflammatory Markers, IL-1α and TGF-β, with Dietary Insulin Load and Dietary Insulin Index in Overweight and Obese Women with Healthy and Unhealthy Metabolic Phenotypes: A Cross-Sectional Study. [PDF]
Int J Clin Pract, 2022 Noori S +7 more
europepmc +1 more source
Gut MicrobiomeMetabolic dietary patterns, including the Empirical Dietary Index for Hyperinsulinaemia (EDIH) and Empirical Dietary Inflammatory Pattern (EDIP), are known to impact multiple chronic diseases, but the role of the colonic microbiome in mediating such ...
Ni Shi +9 more
doaj +1 more source