Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
, 2016 BACKGROUND: Despite increased use of dietary pattern methods in nutritional epidemiology, there have been few direct comparisons of methods. Older adults are a particularly understudied population in the dietary pattern literature.
Crawford, David +3 more
core +1 more source
Modeling of influential predictors of gastric cancer incidence rates in Golestan Province, North Iran [PDF]
, 2014 Golestan province has a reputation for relatively high incidence rates of gastric cancer in Iran. Along with dietary, lifestyle and environmental influential factors, soil selenium and high levels of pesticide used may exert influence in this region. The
Behnampour, N. +3 more
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
TRIVALENT CHROMIUM (CR+3) IN DIETARY CARBOHYDRATE AND ITS EFFECT ON THE GROWTH OF COMMONLY CULTIVATED FISH [PDF]
, 2016 Trivalent chromium (Cr+3) is an essential trace mineral for fish bio-physiological functions. Researches on Cr+3 in the form of organic compound indicated that the mineral affected the bio-activity of insulin, the blood glucose influx, and subsequently ...
Hastuti, Sri, Subandiyono, Subandiyono
core
Projected health effects of realistic dietary changes to address freshwater constraints in India : a modelling study [PDF]
, 2017 Acknowledgements This study forms part of the Sustainable and Healthy Diets in India project supported by the Wellcome Trust's Our Planet, Our Health programme (grant number 103932). LA's PhD is funded by the Leverhulme Centre for Integrative Research on
Agrawal, Sutapa +8 more
core +2 more sources
The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley +1 more source
Survey of Patterns and Habit of Food among Girl Teenage in Kiar School [PDF]
, 2015 Introduction adolescent on evidence little is There. habits and pattern dietary establishing for life in stage important most the is Adolescence .adolescents girl keiar among patterns food determine to was study this of aim The.
Abdizadeh, Fereshteh. +3 more
core +1 more source
Long Sleep Duration and Social Jetlag Are Associated Inversely with a Healthy Dietary Pattern in Adults: Results from the UK National Diet and Nutrition Survey Rolling Programme Y1⁻4. [PDF]
, 2018 Limited observational studies have described the relationship between sleep duration and overall diet. The present study investigated the association between sleep duration on weekdays or social jetlag and empirically derived dietary patterns in a ...
Almoosawi, Suzana +4 more
core +3 more sources
Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew +11 more
wiley +1 more source