Results 71 to 80 of about 253,388 (311)

A DASH dietary pattern and the risk of colorectal cancer in Canadian adults

, 2015
Introduction: Colorectal cancer (CRC) is a high incidence cancer affecting many Canadian adults each year. Diet is important in the etiology of CRC with many dietary components identified as potential risk factors.
J. Hu, M. de Groh, E. Jones-McLean, L. S. Greene-Finestone   +3 more
core   +1 more source

Modern dietary pattern is prospectively associated with earlier age at menarche: data from the CHNS 1997–2015

Nutrition Journal, 2020
Background Early age at menarche is associated with risk of several chronic diseases. Prospective study on the association between dietary pattern and timing of menarche is sparse.
Ruonan Duan, Yue Chen, Tian Qiao, Ruotong Duan, Mengxue Chen, Li Zhao, Yunhui Gong, Guo Cheng   +7 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A social-ecological trap theory-informed investigation of dietary patterns in southwestern Madagascar

Frontiers in Nutrition
BackgroundSocial-ecological trap theory highlights the potential for food systems and the social and environmental contexts within which they are situated to ‘trap’ individuals into a trajectory of specific nutritional outcomes when their physical or ...
Heather Kelahan, Stephanie M. Wu, Hervet Randriamady, Aroniaina Falinirina, Madeleine Rasoanirina, Frédéric Déclerque, Marc Y. Solofoarimanana, Jean C. Mahefa, Eric B. Rimm, Eric B. Rimm, Jessica Fanzo, Aaron C. Hartmann, Aaron C. Hartmann, Emma Gibbons, Gildas Todinanahary, Sebastien Haneuse, Christopher D. Golden   +16 more
doaj   +1 more source

Dietary patterns and colorectal cancer

Clinical Nutrition, 2017
Dietary pattern and lifestyle have been reported to be important risk factors in the development of colorectal cancer (CRC). However, the mechanism of action of dietary factors in CRC disease is unclear. The aim of this study is the examination of several dietary choices and their potential association with the risk of developing CRC.Dietary data was ...
Tayyem, Reema F., Bawadi, Hiba A., Shehadah, Ihab, Agraib, Lana M., AbuMweis, Suhad S., Al-Jaberi, Tareq, Al-Nusairr, Majed, Bani-Hani, Kamal E., Heath, Dennis D.   +8 more
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Molar macrowear reveals Neanderthal eco-geographic dietary variation

, 2011
Neanderthal diets are reported to be based mainly on the consumption of large and medium sized herbivores, while the exploitation of other food types including plants has also been demonstrated.
Kullmer, Ottmar, Luca Fiorenza, Stefano Benazzi, Friedemann Schrenk, Bromage, Timothy G., Tausch, Jeremy, Timothy G Bromage, Bromage, Timothy, Jeremy Tausch, Timothy G. Bromage, Fiorenza, Luca, Benazzi, Stefano, Schrenk, Friedemann, Ottmar Kullmer   +13 more
core   +1 more source

Analysis of dietary inflammatory index in rural elderly based on Frequency Food Questionnaire 25

Huli yanjiu, 2022
ObjectiveTo analyze dietary inflammatory index in rural elderly based on Frequency Food Questionnaire 25.MethodsA total of 599 elderly people in rural areas of Yinchuan city and Wuzhong city in Ningxia Hui Autonomous Region were selected as research ...
LYU Xiongxiong, CHEN Li, NING Yanhua, GUO Haoqian, JIANG Ting, CHEN Kexin, LI Meiman   +6 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source