Results 61 to 70 of about 508,795 (291)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Fanconi syndrome with acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report

BMC Nephrology
Background Fanconi syndrome is a disorder of the proximal tubule that leads to malabsorption of various electrolytes and substances and is a common consequence of drug-induced nephrotoxicity.
Masato Habuka, Michihiro Hosojima, Yusuke Yata, Kenshiro Kurumada, Moeri Yamagiwa, Masataka Yonezawa, Masanori Sudo, Hideyuki Kabasawa, Asa Ogawa, Hitomi Hama, Yumi Ito, Naofumi Imai, Suguru Yamamoto, Akihiko Saito, Shin Goto   +14 more
doaj   +1 more source

Selenium supplementation of lactating dairy cows: effects on milk production and total selenium content and speciation in blood, milk and cheese [PDF]

, 2008
Forty-multiparous Holstein cows were used in a 16-wk continuous design study to determine the effects of either selenium (Se) source, selenized yeast (SY) (derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060 Sel-Plex®) or sodium ...
Bertin, Gérard, Grandison, Alistair Steven, Jones, Andrew Keith, Juniper, Darren Thomas, Phipps, Richard Hartley, Ramos-Morales, Eva   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of Curcumin Supplement in Summer Diet on Blood Metabolites, Antioxidant Status, Immune Response, and Testicular Gene Expression in Hu Sheep

Animals, 2019
In summer, the high temperature affects animal growth and reproductive performance. Curcumin is a flavonoid with anti-oxidant and anti-inflammatory effects.
Zhiyang Jiang, Yongjie Wan, Peng Li, Yang Xue, Wenwen Cui, Qi Chen, Jianqin Chen, Feng Wang, Dagan Mao   +8 more
doaj   +1 more source

Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies [PDF]

, 2015
By reducing energy density, low-energy sweeteners (LES) might be expected to reduce energy intake (EI) and body weight (BW). To assess the totality of the evidence testing the null hypothesis that LES exposure (versus sugars or unsweetened alternatives ...
de Graaf, C, Higgs, S, Hogenkamp, P S, Lluch, A, Mela, D J, Ness, A R, Penfold, C, Perry, R, Putz, P, Rogers, P J, Yeomans, M R   +10 more
core   +5 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Dietary supplement use is common in older adult drivers: an analysis from the AAA LongROAD study

BMC Complementary Medicine and Therapies
Background Dietary supplement (DS) use is common and increasing among older adults, though much data available on use frequencies are from surveys and performed cross-sectionally.
Ryan Moran, Sara Baird, Carolyn G. DiGuiseppi, David W. Eby, Sarah Hacker, Chelsea Isom, Vanya Jones, Kelly C. Lee, Guohua Li, Lisa J. Molnar, Rudy Patrick, David Strogatz, Linda Hill   +12 more
doaj   +1 more source

The Tobacco Diaries: Lessons Learned and Applied to Regulation of Dietary Supplements [PDF]

, 2013
This Article examines the future role of the FDA in the regulation of the dietary supplement industry. To address the role of the FDA in the twenty-first century with respect to the dietary supplement industry, Part I of this Article begins by describing
Sax, Joanna K.
core   +1 more source

Nutraceutical-based integrative medicine: adopting a mediterranean diet pyramid for attaining healthy ageing in veterans with disabilities [PDF]

, 2018
Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans.
Aiello, Paola, Buccolieri, Cosimo, Catasta, Giovina, Ciccotti, Mario, Lista, Florigio, Palmery, Maura, Peluso, Ilaria, Raguzzini, Anna, Reggi, Raffaella, Sciarra, Tommaso   +9 more
core   +1 more source