Results 1 to 10 of about 2,037,406 (347)

Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women’s breast tissue

Scientific Reports, 2023
Breast cancer risk continues to increase post menopause. Anti-estrogen therapies are available to prevent postmenopausal breast cancer in high-risk women. However, their adverse effects have reduced acceptability and overall success in cancer prevention.
Atieh Hajirahimkhan, Caitlin Howell, Elizabeth T. Bartom, Huali Dong, Daniel D. Lantvit, Xiaoling Xuei, Shao-Nong Chen, Guido F. Pauli, Judy L. Bolton, Susan E. Clare, Seema A. Khan, Birgit M. Dietz   +11 more
doaj   +1 more source

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj   +1 more source

Allelic and Genotype Frequencies of CYP2B6∗2 (64C > T) and CYP2B6∗3 (777C > A) in Three Dominant Ethnicities of the Iranian Population

Genetics Research, 2023
Background. Cytochrome P450 complex plays a key role in drug metabolism. CYP2B6 has an essential part in Cytochrome P450 complex metabolism. This study aims to determine the allelic distribution of CYP2B6∗2 and CYP2B6∗3 in three main Iranian ethnicities:
Armin Khavandegar, Bahareh Tavakoli-Far, Sarina Ansari, Parisa Veis-Karami, Faezeh Ghasemi, Samira Sheibaninia, Roshanak Jazayeri, Massoud Houshmand   +7 more
doaj   +1 more source

Peripheral Blood DNA Methylation Changes in Response to Centella asiatica Treatment in Aged Mice

Biology
Alterations in epigenetic modifications, like DNA methylation, in peripheral blood could serve as a useful, minimally invasive biomarker of the effects of anti-aging interventions.
Olivia Monestime, Brett A. Davis, Cora Layman, Kandace J. Wheeler, Wyatt Hack, Jonathan A. Zweig, Amala Soumyanath, Lucia Carbone, Nora E. Gray   +8 more
doaj   +1 more source

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of administration

Frontiers in Aging
Background: A water extract (CAW) of the Ayurvedic plant Centella asiatica administered in drinking water has been shown to improve cognitive deficits in mouse models of aging and neurodegenerative diseases.
Nora E. Gray, Nora E. Gray, Wyatt Hack, Wyatt Hack, Mikah S. Brandes, Mikah S. Brandes, Jonathan A. Zweig, Jonathan A. Zweig, Liping Yang, Liping Yang, Luke Marney, Luke Marney, Jaewoo Choi, Jaewoo Choi, Armando Alcazar Magana, Armando Alcazar Magana, Natasha Cerruti, Natasha Cerruti, Janis McFerrin, Janis McFerrin, Seiji Koike, Seiji Koike, Thuan Nguyen, Thuan Nguyen, Jacob Raber, Jacob Raber, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Claudia S. Maier, Claudia S. Maier, Claudia S. Maier, Amala Soumyanath, Amala Soumyanath   +33 more
doaj   +1 more source

Seven distinct dietary patterns identified among pregnant Finnish women--associations with nutrient intake and sociodemographic factors. [PDF]

, 2007
OBJECTIVES: To identify and describe dietary patterns in a cohort of pregnant women and investigate whether the dietary patterns are associated with dietary intake and sociodemographic factors.
Veijola, Riitta, Suvi M Virtanen, Kenward, Michael G, Mikko Virtanen, Männistö, Satu, Marja-Leena Ovaskainen, Riitta Veijola, Michael G Kenward, Tuula Arkkola, Virtanen, Mikko, Mikael Knip, Knip, Mikael, Arkkola, Tuula, Uusitalo, Ulla, Ulla Uusitalo, Satu Männistö, Kronberg-Kippilä, Carina, Ovaskainen, Marja-Leena, Virtanen, Suvi M, Carina Kronberg-Kippilä   +19 more
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Withania somnifera (Ashwagandha) Improves Spatial Memory, Anxiety and Depressive-like Behavior in the 5xFAD Mouse Model of Alzheimer’s Disease

Antioxidants
Withania somnifera (WS), also known as ashwagandha, is a popular botanical supplement used to treat various conditions including memory loss, anxiety and depression.
Noah Gladen-Kolarsky, Olivia Monestime, Melissa Bollen, Jaewoo Choi, Liping Yang, Armando Alcazar Magaña, Claudia S. Maier, Amala Soumyanath, Nora E. Gray   +8 more
doaj   +1 more source

Vaginal and oral probiotics effect in the prevention of preterm delivery in patients visiting Kamali Hospital, Karaj, Iran in 2020

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2022
Introduction: The prevalence of preterm labor (PTL) is growing, and annually one in ten babies is born prematurely. Various studies have examined the effect of oral or vaginal probiotics on the prevention of preterm labor, which has yielded contrasting ...
Elahe Solgi, Bahareh Tavakoli-Far, Bita Badehnoosh, Armin Khavandegar, Mahmood Bakhtiyari   +4 more
doaj   +1 more source

Liquid chromatography-mass spectrometry quantification of phytochemicals in Withania somnifera using data-dependent acquisition, multiple-reaction-monitoring, and parallel-reaction-monitoring with an inclusion list

Frontiers in Chemistry
Characterization of botanical extracts by mass spectrometry-based metabolomics analysis helps in determining the phytochemical composition that underlies their bioactivity and potential health benefits, while also supporting reproducibility of effects in
Luke C. Marney, Luke C. Marney, Jaewoo Choi, Jaewoo Choi, Armando Alcazar Magana, Armando Alcazar Magana, Armando Alcazar Magana, Liping Yang, Liping Yang, Natascha Techen, Natascha Techen, Md Nure Alam, Md Nure Alam, Mikah Brandes, Mikah Brandes, Amala Soumyanath, Amala Soumyanath, Jan F. Stevens, Jan F. Stevens, Jan F. Stevens, Claudia S. Maier, Claudia S. Maier, Claudia S. Maier   +22 more
doaj   +1 more source

A profile of dietary supplement use of elderly in two Wisconsin counties [PDF]

, 2000
Plan BThe use of alternative therapies in the United States is growing rapidly. (Studdert et al 1998) Herbal and dietary supplements are used by more than fifty percent of the U.S. population.
Amy, Lesa
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