Results 41 to 50 of about 159,109 (263)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Dietary Supplement Nomenclature

The Primary Care Companion For CNS Disorders, 2016
To the Editor: We very much appreciate Arnold and colleagues’ letter1 and their thoughtful suggestions. The case report by Wong et al2 carefully addressed the concerns regarding nomenclature of supplements as well as the governmental regulations regarding advertising of these increasingly used products.
Michelle K, Wong, Ayeh, Darvishzadeh, Neal A, Maler, Robert G, Bota   +3 more
openaire   +3 more sources

Genotypes pattern of Hepatitis C virus infection in Kermanshah city [PDF]

Journal of Microbiology and Infectious Diseases, 2014
One of the most common causes of chronic liver disease is Hepatitis C all over the world. Furthermore, WHO estimated that the prevalence of HCV isalmost 2-3%,1,2 nonetheless, many studies reported the considerable differences on geographical point of ...
Kioumars Pourrostami, Manoochehr Karami , Enayatollah Kalantar , Feizollah Mansouri   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Multi-Omics Analysis in Mouse Primary Cortical Neurons Reveals Complex Positive and Negative Biological Interactions Between Constituent Compounds of Centella asiatica

Pharmaceuticals
Background: A water extract of the Ayurvedic plant Centella asiatica (L.) Urban, family Apiaceae (CAW), improves cognitive function in mouse models of aging and Alzheimer’s disease and affects dendritic arborization, mitochondrial activity, and oxidative
Steven R. Chamberlin, Jonathan A. Zweig, Cody J. Neff, Luke Marney, Jaewoo Choi, Liping Yang, Claudia S. Maier, Amala Soumyanath, Shannon McWeeney, Nora E. Gray   +9 more
doaj   +1 more source

Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters

Acta Pharmaceutica, 2014
There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB).
Mrozikiewicz Przemyslaw M., Bogacz Anna, Bartkowiak-Wieczorek Joanna, Kujawski Radoslaw, Mikolajczak Przemyslaw L., Ozarowski Marcin, Czerny Boguslaw, Mrozikiewicz-Rakowska Beata, Grzeskowiak Edmund   +8 more
doaj   +1 more source

The relationship of supportive roles with mental health and satisfaction with life in female household heads in Karaj, Iran: a structural equations model

BMC Public Health, 2021
Background Female household heads are faced with more problems than men due to their multiple concurrent roles. The present study was conducted to determine the relationship of supportive roles with mental health and satisfaction with life in female ...
Nooshin Shadabi, Sara Esmaelzadeh Saeieh, Mostafa Qorbani, Touran Bahrami Babaheidari, Zohreh Mahmoodi   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source