Results 51 to 60 of about 840,652 (300)

Determination of Total Antioxidant Capacity in Saliva of Smokers and Non-smokers with Chronic Periodontitis

Bihdād, 2020
Background: Periodontal diseases in smokers are 2.6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is ...
Ahmadreza Mirzaei, Mahboobeh Mehrabani, Zohreh Khodaii, Hamid Mirshamsi, Nasrin Rafieian   +4 more
doaj  

Assessment of expression of calcium signaling related lncRNAs in epilepsy

Scientific Reports, 2023
Calcium signaling is a metabolic pathway that is essential in neurons development and can be involved in the pathobiology of epilepsy. We assessed expression of three mRNA coding gene (SLC1A1, SLC25A12, and ATP2B2) and three related long non-coding RNAs (
Mohammad Taheri, Ashkan Pourtavakoli, Solat Eslami, Soudeh Ghafouri-Fard, Arezou Sayad   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Mode of administration influences plasma levels of active Centella asiatica compounds in 5xFAD mice while markers of neuroinflammation remain unaltered

Frontiers in Neuroscience
IntroductionA water extract of Centella asiatica (L.) Urban [Apiaceae] (CAW) has demonstrated cognitive-enhancing effects in mouse models of Alzheimer’s disease and aging, the magnitude of which is influenced by whether CAW is delivered in the drinking ...
Alex B. Speers, Alex B. Speers, Kirsten M. Wright, Kirsten M. Wright, Mikah S. Brandes, Mikah S. Brandes, Nareg Kedjejian, Nareg Kedjejian, Donald G. Matthews, Maya Caruso, Christopher J. Harris, Seiji Koike, Seiji Koike, Thuan Nguyen, Thuan Nguyen, Joseph F. Quinn, Joseph F. Quinn, Joseph F. Quinn, Amala Soumyanath, Amala Soumyanath, Nora E. Gray, Nora E. Gray   +21 more
doaj   +1 more source

A comprehensive review of the application of probiotics and postbiotics in oral health

Frontiers in Cellular and Infection Microbiology, 2023
Oral diseases are among the most common diseases around the world that people usually suffer from during their lifetime. Tooth decay is a multifactorial disease, and the composition of oral microbiota is a critical factor in its development.
Aziz Homayouni Rad, Hadi Pourjafar, Esmaeel Mirzakhani   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

DIETARY SUPPLEMENTS CONSUMPTION AMONG SPORTSMEN INLEBANON [PDF]

, 2020
The prevalence and the precipitated factors of dietary supplements use among sportsmen is poorly investigated in Lebanon. This study aim to assess the prevalence of dietary supplements use among sportsmen in Lebanon and affecting factors.
ABOU Al Naga3, AZZA, Professor, Department of Clinical Sciences, Faculty of Medicine, AZAKIR, BILAL, Assistant Professor, Department of Basic Medical Sciences, Faculty of Medicine, ABOU DAHER2, GHAYDAA, Faculty of Medicine   +2 more
core   +1 more source

Genotypes pattern of Hepatitis C virus infection in Kermanshah city [PDF]

Journal of Microbiology and Infectious Diseases, 2014
One of the most common causes of chronic liver disease is Hepatitis C all over the world. Furthermore, WHO estimated that the prevalence of HCV isalmost 2-3%,1,2 nonetheless, many studies reported the considerable differences on geographical point of ...
Kioumars Pourrostami, Manoochehr Karami , Enayatollah Kalantar , Feizollah Mansouri   +3 more
doaj   +1 more source