Results 61 to 70 of about 2,037,406 (347)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dietary Supplement Nomenclature

The Primary Care Companion For CNS Disorders, 2016
To the Editor: We very much appreciate Arnold and colleagues’ letter1 and their thoughtful suggestions. The case report by Wong et al2 carefully addressed the concerns regarding nomenclature of supplements as well as the governmental regulations regarding advertising of these increasingly used products.
Michelle K, Wong, Ayeh, Darvishzadeh, Neal A, Maler, Robert G, Bota   +3 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Centella asiatica and its caffeoylquinic acid and triterpene constituents increase dendritic arborization of mouse primary hippocampal neurons and improve age-related locomotion deficits in Drosophila

Frontiers in Aging
IntroductionCentella asiatica (CA) is known in Ayurvedic medicine as a rejuvenating herb with particular benefits in the nervous system. Two groups of specialized metabolites found in CA and purported to contribute to its beneficial effects are ...
Karon Rowe, Karon Rowe, Nora E. Gray, Nora E. Gray, Jonathan A. Zweig, Jonathan A. Zweig, Alexander Law, Alexander Law, Natascha Techen, Natascha Techen, Claudia S. Maier, Claudia S. Maier, Claudia S. Maier, Amala Soumyanath, Amala Soumyanath, Doris Kretzschmar, Doris Kretzschmar   +16 more
doaj   +1 more source

Term Coverage of Dietary Supplements in Product Labels

, 2016
Includes lstProducts.csv, Python scripts (version 3), and output text files. See Readme.txt for more detail.The data includes the Python source code for downloading, extracting and normalizing the dietary supplement ingredients information in Dietary ...
Wang, Yefeng
core   +1 more source

Knowledge, attitude, and practices regarding dietary supplements in Saudi Arabia

Journal of Family Medicine and Primary Care, 2019
Objective: The study was aimed at determining the characteristics and lifestyle choices of dietary supplement users and to assess knowledge, attitude, and practice related to dietary supplements in the health sciences students versus other individuals in
M. Alowais, M. Selim
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Determination of Total Antioxidant Capacity in Saliva of Smokers and Non-smokers with Chronic Periodontitis

Bihdād, 2020
Background: Periodontal diseases in smokers are 2.6 to 6 times higher than non-smokers and their response to treatment is much lower. Reducing levels of antioxidants and consequently increasing oxidative damage in the pathogenesis of periodontitis is ...
Ahmadreza Mirzaei, Mahboobeh Mehrabani, Zohreh Khodaii, Hamid Mirshamsi, Nasrin Rafieian   +4 more
doaj  

Assessment of expression of calcium signaling related lncRNAs in epilepsy

Scientific Reports, 2023
Calcium signaling is a metabolic pathway that is essential in neurons development and can be involved in the pathobiology of epilepsy. We assessed expression of three mRNA coding gene (SLC1A1, SLC25A12, and ATP2B2) and three related long non-coding RNAs (
Mohammad Taheri, Ashkan Pourtavakoli, Solat Eslami, Soudeh Ghafouri-Fard, Arezou Sayad   +4 more
doaj   +1 more source